Abbott IMx® evaluated for assay of prostate-specific antigen in serum Journal Article
| Authors: | Dnistrian, A. M.; Schwartz, M. K.; Smith, C. A.; Nisselbaum, J. S.; Fair, W. R. |
| Article Title: | Abbott IMx® evaluated for assay of prostate-specific antigen in serum |
| Abstract: | We evaluated a new fully automated procedure for quantitative measurement of prostate-specific antigen (PSA) by the Microparticle Enzyme Immunoassay (MEIA) technology developed for the Abbott IMx® automated immunoassay system. The performance characteristics of the Abbott IMx PSA assay (y) were evaluated and compared with those of the Hybritech Tandem®-E PSA assay (x), a solid-phase two-site immunoenzymometric assay. PSA values for both assays were well correlated (r = 0.99); regression analysis yielded the equation y = 0.92x - 0.23 μg/L. The Abbott assay proved reliable and reproducible, as shown by the intra- and interassay coefficients of variation (2.0-3.4% and 3.1-4.7%, respectively). The assay gave a linear standard curve up to 100 μg/L and was very sensitive (detected PSA <0.1 μg/L). This analytical sensitivity was comparable with that of the Tandem-E PSA assay. Overall, the IMx PSA assay demonstrated the accuracy, precision, linearity, and intermethod correlation required for monitoring patients with prostate cancer. |
| Keywords: | comparative study; reproducibility; prostate specific antigen; accuracy; patient monitoring; prostate cancer; prostate-specific antigen; standard; enzyme immunoassay; immunoenzyme techniques; blood; intermethod comparison; immunoassay; regression analysis; autoanalysis; reagent kits, diagnostic; analytical equipment; human; male; priority journal; article |
| Journal Title: | Clinical Chemistry |
| Volume: | 38 |
| Issue: | 10 |
| ISSN: | 0009-9147 |
| Publisher: | American Association for Clinical Chemistry |
| Date Published: | 1992-10-01 |
| Start Page: | 2140 |
| End Page: | 2142 |
| Language: | English |
| PUBMED: | 1382898 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
Citation Impact
MSK Authors
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78Dnistrian -
342Fair -
186
Schwartz -
20
Nisselbaum -
39
Smith
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