Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors Journal Article

  


Authors: Attisano, L.; Wrana, J. L.; Cheifetz, S.; Massagué, J.
Article Title: Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
Abstract: We have cloned ActR-IIB, which encodes four new activin receptor isoforms belonging to the protein serine/threonine kinase receptor family. Two of the ActR-IIB isoforms have higher affinity for activin A than the previously cloned activin receptor and differ from each other by the inclusion of an alternatively spliced segment in the cytoplasmic juxtamembrane region. A second alternative splicing event generates two additional receptor isoforms that lack a proline cluster in the external juxtamembrane region and have lower affinity for activin A. All isoforms bind inhibin A with low affinity. Thus, the repertoire of activin receptors includes species that differ in ligand binding affinity, cytoplasmic domain structure, or both. This receptor heterogeneity might underlie the sharply different responses that activin can elicit in a dose- or cell-specific manner. © 1992.
Keywords: nonhuman; comparative study; polymerase chain reaction; animal; mice; gene expression; protein kinases; cell line; transfection; protein serine threonine kinase; molecular cloning; cloning, molecular; amino acid sequence; molecular sequence data; rna, messenger; recombinant proteins; cell membrane; alternative rna splicing; base sequence; dna sequence; receptor; sequence homology, nucleic acid; rna splicing; 3t3 cells; multigene family; receptors, cell surface; inhibin; activin; activins; priority journal; article; inhibins; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; activin receptors
Journal Title: Cell
Volume: 68
Issue: 1
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 1992-01-01
Start Page: 97
End Page: 108
Language: English
DOI: 10.1016/0092-8674(92)90209-u
PUBMED: 1310075
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026527384&doi=10.1016%2f0092-8674%2892%2990209-U&partnerID=40&md5=91993b274620b5b6dd78df3b02f8e413
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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MSK Authors
  1. Joan Massague
    388 Massague
  2. Jeff Wrana
    39 Wrana
  3. Liliana Attisano
    30 Attisano
  4. Sela Cheifetz
    16 Cheifetz
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