Transient sialoadenitis: A complication of 131I- metaiodobenzylguanidine therapy Journal Article

  


Authors: Modak, S.; Pandit-Taskar, N.; Kushner, B. H.; Kramer, K.; Smith-Jones, P.; Larson, S.; Cheung, N. K. V.
Article Title: Transient sialoadenitis: A complication of 131I- metaiodobenzylguanidine therapy
Abstract: Radioiodinated metaiodobenzylguanidine [131I-MIBG] is commonly used to treat resistant neuroblastoma or metastatic pheochromocytoma [MP] with little non-hematopoietic toxicity. We describe here transient sialoadenitis, a previously unreported complication. Ten patients [9 neuroblastoma and 1 MP] received 12-18 mCi/kg of 131I-MIBG. Five patients had bilateral parotid swelling, two with associated buccal discomfort within 24 hr of injection which subsided within 48 hr. Grade 3 or 4 serum amylase elevation was documented in 8/8 patients tested [median 1,336; range: 576-8,830 U/L] which normalized [25-125 U/L] within 4-14 [median 5.5] days. Serum lipase remained normal. Patients did not develop subsequent dry mouth or dysphagia. © 2007 Wiley-Liss, Inc.
Keywords: adolescent; child; clinical article; controlled study; child, preschool; side effect; antineoplastic agents; cancer radiotherapy; radiopharmaceuticals; dysphagia; neuroblastoma; 3-iodobenzylguanidine; xerostomia; erythema; single drug dose; nausea and vomiting; (3 iodobenzyl)guanidine i 131; pheochromocytoma; amylase blood level; triacylglycerol lipase blood level; liothyronine; amylase; amylases; triacylglycerol lipase; sialoadenitis; sialadenitis; hyperamylasemia; salivation; malignant pheochromocytoma; mibg therapy; chewing discomfort; facial discomfort; jaw pain; parotid enlargement; parotid swelling
Journal Title: Pediatric Blood and Cancer
Volume: 50
Issue: 6
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2008-06-01
Start Page: 1271
End Page: 1273
Language: English
DOI: 10.1002/pbc.21391
PUBMED: 17973318
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-42349094437&partnerID=40&md5=f79bbd7f07e62667fff5d7b2e77d4f2f
Notes: --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: PBCEA" - "Source: Scopus"
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MSK Authors
  1. Brian Kushner
    311 Kushner
  2. Nai-Kong Cheung
    648 Cheung
  3. Kim Kramer
    236 Kramer
  4. Shakeel Modak
    249 Modak
  5. Neeta Pandit-Taskar
    342 Pandit-Taskar
  6. Peter Smith-Jones
    67 Smith-Jones
  7. Steven M Larson
    958 Larson
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