Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia Journal Article
| Authors: | Huang, M. T.; Deschner, E. E.; Newmark, H. L.; Wang, Z. Y.; Ferraro, T. A.; Conney, A. H. |
| Article Title: | Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia |
| Abstract: | Curcumin, a major yellow pigment of turmeric obtained from powdered rhizomes of the plant Curcuma longa Linn., is commonly used as a coloring agent in foods, drugs and cosmetics. Ascorbyl palmitate is a lipid soluble derivative of ascorbic acid. Both curcumin and ascorbyl palmitate have antioxidant activity and are potent inhibitors of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. The effects of dietary curcumin and ascorbyl palmitate on azoxymethanol (AOM)-induced hyperproliferation of colonic epithelial cells and the incidence of focal areas of dysplasia (FADs) were evaluated in female CF-1 mice fed an AIN 76A diet. Subcutaneous injections of AOM (10 mg/kg body wt. once weekly for 6 weeks) caused hyperplasia and the formation of FADs in the colon. Administration of 2% curcumin in the diet inhibited AOM-induced formation of FADs while administration of 2% ascorbyl palmitate in the diet did not demonstrate inhibition. This result suggests that dietary curcumin may inhibit AOM-induced colonic neoplasia in mice. © 1992. |
| Keywords: | controlled study; nonhuman; comparative study; animal cell; mouse; animal; mice; animal tissue; cell growth; animal experiment; body weight; animalia; diet; hyperplasia; epithelium cell; antioxidants; ascorbic acid; epithelium; colon; curcuma longa; curcumin; dysplasia; colon carcinogenesis; oral drug administration; tetradecanoylphorbol acetate; colon mucosa; hyperproliferation; female; priority journal; article; support, u.s. gov't, p.h.s.; methylazoxymethanol acetate; ascorbyl palmitate; azoxymethanol; colonic epithelial cells; focal areas of dysplasia; azoxy derivative |
| Journal Title: | Cancer Letters |
| Volume: | 64 |
| Issue: | 2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 1992-06-15 |
| Start Page: | 117 |
| End Page: | 121 |
| Language: | English |
| DOI: | 10.1016/0304-3835(92)90071-3 |
| PUBMED: | 1611594 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
