t(12;22)(q13;q13) and trisomy 8 are nonrandom aberrations in clear-cell sarcoma Journal Article
| Authors: | Rodriguez, E.; Sreekantaiah, C.; Reuter, V. E.; Motzer, R. J.; Chaganti, R. S. K. |
| Article Title: | t(12;22)(q13;q13) and trisomy 8 are nonrandom aberrations in clear-cell sarcoma |
| Abstract: | We report a case of clear-cell sarcoma with a t(12;22)(q13;q13) and multiple copies of chromosome 8 in addition to other abnormalities. An identical or similar translocation has previously been reported in this type of tumor, suggesting that the t(12;22) is a primary cytogenetic change in the pathogenesis of a subset of clear-cell sarcomas. In addition, the presence of extra copies of chromosome 8, commonly noted in our case and others, suggests that it represents a nonrandom secondary change in these tumors. © 1992. |
| Keywords: | immunohistochemistry; adult; human tissue; case report; lymphatic metastasis; chromosomes, human, pair 8; sarcoma; testicular neoplasms; chromosome aberrations; karyotyping; chromosome 12q; soft tissue neoplasms; clear cell sarcoma; chromosome 22q; chromosomes, human, pair 22; middle age; trisomy; trisomy 8; chromosomes, human, pair 12; chromosome translocation 22; human; male; priority journal; article; chromosome translocation 12; translocation (genetics) |
| Journal Title: | Cancer Genetics and Cytogenetics |
| Volume: | 64 |
| Issue: | 2 |
| ISSN: | 0165-4608 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1992-12-01 |
| Start Page: | 107 |
| End Page: | 110 |
| Language: | English |
| DOI: | 10.1016/0165-4608(92)90338-9 |
| PUBMED: | 1486558 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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