| Abstract: |
Subsets of non-Hodgkin's lymphoma in humans have been shown to involve activation of protooncogenes such as MYC and BCL2 resulting from chromosome translocation involving the IGH and TCR genes. Malignant lymphomas in the canine present histologic and clinical subsets similar to those in humans. To study the genetic nature of these lymphomas, we undertook this study to determine, by Southern blotting analysis, the extent of homology between the human and canine genes MYC, BCL2, IGH, and TCRB using human gene probes. Our results, presented here, show that the organization of these genes in the two species is very similar. © 1992. |
| Keywords: |
proto-oncogene proteins; histopathology; nonhuman; animal; gtp-binding proteins; nonhodgkin lymphoma; dog; dogs; genes, myc; lymphoma; species difference; chromosome translocation; sequence homology; sequence homology, nucleic acid; proto-oncogene proteins c-bcl-2; oncogene myc; receptors, antigen, t-cell, alpha-beta; southern blotting; canis familiaris; proto-oncogenes; restriction mapping; blotting, southern; protein-tyrosine kinase; human; priority journal; article; support, u.s. gov't, p.h.s.; immunoglobulins, heavy-chain
|
