Pharmacokinetics of ara-C and ara-U in plasma and CSF after high-dose administration of cytosine arabinoside Journal Article


Authors: DeAngelis, L. M.; Kreis, W.; Chan, K.; Dantis, E.; Akerman, S.
Article Title: Pharmacokinetics of ara-C and ara-U in plasma and CSF after high-dose administration of cytosine arabinoside
Abstract: Cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) levels were measured in the plasma, cerebrospinal fluid (CSF), and urine of 10 patients exhibiting primary central nervous system lymphoma who received 31 infusions of high-dose ara-C (3 g/m2) as part of their treatment regimen. Peak plasma and CSF ara-C levels were 10.8 and 1.5 μg/ml, respectively. Ara-C was cleared more rapidly from plasma than from CSF. Ara-U appeared rapidly in both plasma and CSF, reaching a peak that was 10 times higher than the corresponding ara-C concentration (104 and 11.2 μg/ml, respectively). Only 4%-6% of the dose was excreted unchanged in the urine, but 63%-73% of it appeared as ara-U within the first 24 h. The presence of leptomeningeal lymphoma did not affect the CSF level of ara-C or ara-U. © 1992 Springer-Verlag.
Keywords: adult; cancer chemotherapy; clinical article; combined modality therapy; cytarabine; methotrexate; central nervous system neoplasms; lymphoma; uracil arabinoside; arabinofuranosyluracil; metabolic clearance rate; drug blood level; half-life; intravenous drug administration; middle age; drug cerebrospinal fluid level; human; male; female; priority journal; article; support, non-u.s. gov't
Journal Title: Cancer Chemotherapy and Pharmacology
Volume: 29
Issue: 3
ISSN: 0344-5704
Publisher: Springer  
Date Published: 1992-05-01
Start Page: 173
End Page: 177
Language: English
DOI: 10.1007/bf00686248
PUBMED: 1733548
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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  1. Ester C Dantis
    5 Dantis