Pharmacokinetics of ara-C and ara-U in plasma and CSF after high-dose administration of cytosine arabinoside Journal Article
| Authors: | DeAngelis, L. M.; Kreis, W.; Chan, K.; Dantis, E.; Akerman, S. |
| Article Title: | Pharmacokinetics of ara-C and ara-U in plasma and CSF after high-dose administration of cytosine arabinoside |
| Abstract: | Cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) levels were measured in the plasma, cerebrospinal fluid (CSF), and urine of 10 patients exhibiting primary central nervous system lymphoma who received 31 infusions of high-dose ara-C (3 g/m2) as part of their treatment regimen. Peak plasma and CSF ara-C levels were 10.8 and 1.5 μg/ml, respectively. Ara-C was cleared more rapidly from plasma than from CSF. Ara-U appeared rapidly in both plasma and CSF, reaching a peak that was 10 times higher than the corresponding ara-C concentration (104 and 11.2 μg/ml, respectively). Only 4%-6% of the dose was excreted unchanged in the urine, but 63%-73% of it appeared as ara-U within the first 24 h. The presence of leptomeningeal lymphoma did not affect the CSF level of ara-C or ara-U. © 1992 Springer-Verlag. |
| Keywords: | adult; cancer chemotherapy; clinical article; combined modality therapy; cytarabine; methotrexate; central nervous system neoplasms; lymphoma; uracil arabinoside; arabinofuranosyluracil; metabolic clearance rate; drug blood level; half-life; intravenous drug administration; middle age; drug cerebrospinal fluid level; human; male; female; priority journal; article; support, non-u.s. gov't |
| Journal Title: | Cancer Chemotherapy and Pharmacology |
| Volume: | 29 |
| Issue: | 3 |
| ISSN: | 0344-5704 |
| Publisher: | Springer |
| Date Published: | 1992-05-01 |
| Start Page: | 173 |
| End Page: | 177 |
| Language: | English |
| DOI: | 10.1007/bf00686248 |
| PUBMED: | 1733548 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
