Long‐term treatment results of postoperative radiation therapy for advanced stage oropharyngeal carcinoma Journal Article
| Authors: | Zelefsky, M. J.; Harrison, L. B.; Armstrong, J. G. |
| Article Title: | Long‐term treatment results of postoperative radiation therapy for advanced stage oropharyngeal carcinoma |
| Abstract: | Background. The authors report the long‐term treatment results for advanced stage base of tongue (BOT) and tonsillar fossa (TF) carcinomas treated with surgery and postoperative radiation therapy (RT) at Memorial Sloan‐Kettering Cancer Center. Methods. Between 1973 and 1986, 51 patients with squamous cell carcinoma of the BOT (n = 31 patients) and TF (n = 20 patients) were treated with surgery plus RT. Indication(s) for RT included: advanced disease (Stage T3/T4, 34 patients [66%]); close or positive margins (33 patients, 64%) and multiple positive neck nodes (43 patients, 84%). Results. The 7‐year actuarial local control rates for BOT and TF lesions were 81% and 83%, respectively. Local control was achieved in 17 of 18 (94%) patients with T3 lesions, and 12 of 16 (75%) patients with T4 lesions. Among patients with positive or close margins who received postoperative doses of 60 Gy or more, the long‐term control rate was 93%. The presence of a treatment interruption had a negative effect on the local control rates. The actuarial control among patients who required a treatment break was 64%; for those not requiring interruption of their treatment, the actuarial control was 93% (P = 0.05). At 7 years, the overall survival for all patients was 52y0, and the disease‐free survival was 64%. The actuarial incidence of neck failure was 21% and 18% for BOT and TF, respectively. The likelihood of having distant metastasis at 7 years for all patients was 30%. The actuarial incidence of having a second malignancy was 35% for patients with BOT disease. Second malignancy was not observed among patients with TF lesions. Conclusions. The authors conclude that surgery and postoperative RT can provide excellent long‐term, disease‐control rates for patients with advanced BOT and TF tumors. However, current strategies for BOT lesions have been directed at tongue preservation without surgery. Copyright © 1992 American Cancer Society |
| Keywords: | adult; cancer survival; aged; survival analysis; retrospective studies; major clinical study; cancer recurrence; postoperative period; carcinoma, squamous cell; advanced cancer; cancer radiotherapy; postoperative care; follow-up studies; metastasis; neoplasm recurrence, local; radiotherapy; morbidity; cancer control; tongue neoplasms; tongue carcinoma; tonsillar neoplasms; oropharynx carcinoma; tonsil carcinoma; oropharyngeal neoplasms; middle age; postoperative radiation; neck cancer; tonsillar fossa; human; male; female; priority journal; article; base of tongue |
| Journal Title: | Cancer |
| Volume: | 70 |
| Issue: | 10 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1992-11-15 |
| Start Page: | 2388 |
| End Page: | 2395 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19921115)70:10<2388::Aid-cncr2820701003>3.0.Co;2-m |
| PUBMED: | 1423170 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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