Application of immunohistochemistry to gynecologic pathology Journal Article
| Authors: | Mittal, K.; Soslow, R.; McCluggage, W. G. |
| Article Title: | Application of immunohistochemistry to gynecologic pathology |
| Abstract: | Context. - A large variety of tumors and lesions arise in the female genital tract. Although the majority of these can be correctly recognized on routine hematoxylin-eosin-stained slides, occasional cases present a diagnostic challenge. Immunohistochemical stains are extremely useful in resolving many of these problematic cases. As the knowledge in this area is constantly expanding, it is useful to have this updated information in a review form for easy access. Objective. - To present our current knowledge of immunohistochemistry of the lesions of the female genital tract in a readily accessible form. Data Sources. - The review is based on previously published articles on this topic. Conclusions. - Immunohistochemical stains help in reaching a conclusive diagnosis in a variety of problematic lesions seen in gynecologic pathology. As in any other system, immunohistochemical findings need to be interpreted in light of the clinical history and morphologic findings. |
| Keywords: | immunohistochemistry; review; squamous cell carcinoma; endometrioid carcinoma; endometrium carcinoma; adenocarcinoma; ovary adenocarcinoma; diagnosis, differential; vagina; tumor markers, biological; pathology; morphology; kidney carcinoma; genital neoplasms, female; ovary; prostate; mismatch repair; microsatellite instability; uterine cervix cancer; breast carcinoma; cytoplasm; cell nucleus; clear cell carcinoma; hemangiopericytoma; leiomyosarcoma; colon carcinoma; uterus cancer; gynecology; stomach carcinoma; muscle tumor; trophoblastic tumor; female genital system; sex cord tumor; vulva cancer; leiomyoma; adenomyosis; mesothelium; vulva; paget skin disease; genital diseases, female |
| Journal Title: | Archives of Pathology & Laboratory Medicine |
| Volume: | 132 |
| Issue: | 3 |
| ISSN: | 0003-9985 |
| Publisher: | College of American Pathologists |
| Date Published: | 2008-03-01 |
| Start Page: | 402 |
| End Page: | 423 |
| Language: | English |
| PUBMED: | 18318583 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 22" - "Export Date: 17 November 2011" - "CODEN: ARPAA" - "Source: Scopus" |
