Four cycles of chemotherapy and regional radiation therapy for clinical early‐stage and intermediate‐stage Hodgkin's disease Journal Article
| Authors: | Straus, D. J.; Yahalom, J.; Gaynor, J.; Myers, J.; Koziner, B.; Caravelli, J.; Lee, B. J. 3rd; Nisce, L. Z.; McCormick, B.; Bajorunas, D.; Redman, J.; Kirsch, J.; Clarkson, B. D. |
| Article Title: | Four cycles of chemotherapy and regional radiation therapy for clinical early‐stage and intermediate‐stage Hodgkin's disease |
| Abstract: | To achieve a high percentage of durable complete remissions (CR) and prolonged survivals and reduce toxicity in patients with early‐stage and intermediate‐stage Hodgkin's disease, a randomized trial of four cycles of mech‐Iorethamine, vincristine, procarbazine, and prednisone (MOPP) versus four cycles of thiotepa, bleomycin, and vinblastine (TBV) combined with regional radiation therapy (RT) was conducted. For MOPP and RT, the CR percentage was 98% (60 of 61), and at 5 years, the percentage of patients in CR was 90%, with freedom from progression of 89% and overall survival of 91%. For TBV and RT, the CR percentage was 93% (55 of 59), with a 5‐year duration of CR of 83%, freedom from progression of 81%, and overall survival of 91% (P > 0.15). The median follow‐up was 65 months (range, 7 to 96 months). For 27 patients with clinical Stage IIIA, the CR percentage for MOPP and RT was 75% (12 of 16), with 1 relapse and 4 deaths. For TBV and RT, the CR percentage for clinical Stage IIIA was 73% (8 of 11) with 2 relapses and 2 deaths. Short‐term toxicity except for transient leukopenia was less for TBV and RT than for MOPP and RT. Good results are achievable with combined treatment without excessive toxicity. Cancer 1992; 69:1052–1060. Copyright © 1992 American Cancer Society |
| Keywords: | adolescent; adult; cancer survival; survival analysis; major clinical study; prednisone; cancer combination chemotherapy; cancer radiotherapy; comparative study; combined modality therapy; cancer staging; neurotoxicity; neoplasm staging; leukopenia; antineoplastic combined chemotherapy protocols; drug administration schedule; vincristine; cancer mortality; chlormethine; procarbazine; thiotepa; vinblastine; hodgkin disease; cancer inhibition; gastrointestinal toxicity; cancer regression; remission induction; bleomycin; hypothyroidism; intravenous drug administration; oral drug administration; random allocation; middle age; azoospermia; amenorrhea; subcutaneous drug administration; mechlorethamine; human; male; female; priority journal; article |
| Journal Title: | Cancer |
| Volume: | 69 |
| Issue: | 4 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1992-02-15 |
| Start Page: | 1052 |
| End Page: | 1060 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19920215)69:4<1052::Aid-cncr2820690437>3.0.Co;2-9 |
| PUBMED: | 1370915 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
