Autologous bone marrow transplantation for acute myelogenous leukemia using 4-hydroperoxycyclophosphamide and VP-16 purged bone marrow Journal Article
| Authors: | Gulati, S.; Acaba, L.; Yahalom, J.; Reich, L.; Motzer, R.; Crown, J.; Doherty, M.; Clarkson, B.; Berman, E.; Atzpodien, J.; Andreeff, M.; Gee, T. |
| Article Title: | Autologous bone marrow transplantation for acute myelogenous leukemia using 4-hydroperoxycyclophosphamide and VP-16 purged bone marrow |
| Abstract: | Thirty adult patients with acute myelogenous leukemia (AML) in remission were treated with hyperfractionated total body irradiation, VP-16, and cyclophosphamide followed by infusion of autologous bone marrow purged with 4-hydroperoxycyclophosphamide and VP-16. Fifteen patients were transplanted in first remission (R1), 13 in second remission (R2), and two in third remission (R3). All patients had hematopoietic engraftment. The median time to achieve a white blood cell count of 1.0 x 109/l and a neutrophil count of 500 x 106/l was 32 days. The median time to achieve an unsupported platelet count of 50 x 109/l was 70 days. There were four transplant-related deaths, all in patients in R2. Ten patients have relapsed, including both patients transplanted in R3. The disease-free survival (DFS) of all patients is 52%, median follow-up not yet reached. Although the number of patients in each group is small and follow-up is limited, there is a trend toward improved actuarial DFS in patients transplanted in R1 compared with patients transplanted in R2 (72 vs 39%; p = 0.081). Use of VP-16 in the conditioning regimen as well as in the purging procedure is feasible in the treatment of patients with AML. |
| Keywords: | survival; adult; clinical article; survival rate; acute granulocytic leukemia; cytarabine; follow-up studies; etoposide; relapse; cyclophosphamide; whole body radiation; neutrophil; daunorubicin; thrombocyte count; remission; leukocyte count; idarubicin; amsacrine; bone marrow transplantation; tioguanine; autologous bone marrow transplantation; middle age; bone marrow purging; leukemia, myelocytic, acute; 4 hydroperoxycyclophosphamide; human; male; female; article; support, non-u.s. gov't |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 10 |
| Issue: | 2 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1992-08-01 |
| Start Page: | 129 |
| End Page: | 134 |
| Language: | English |
| PUBMED: | 1525601 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
