Radiation-associated sarcoma of bone and soft tissue Conference Paper
| Authors: | Brady, M. S.; Gaynor, J. J.; Brennan, M. F. |
| Title: | Radiation-associated sarcoma of bone and soft tissue |
| Conference Title: | 45th Annual Cancer Symposium of the Society of Surgical Oncology |
| Abstract: | Radiation-associated sarcomas are uncommon, constituting less than 5% of all sarcomas, and generally associated with a poor prognosis. We reviewed the medical records of 565 patients with sarcoma and a second malignancy seen at our institution between 1943 and 1989; 160 of these patients (28%) were considered to have a radiation-associated sarcoma. The most common diagnosis for which radiation had been given was breast cancer (26%), followed by lymphoma (25%) and carcinoma of the cervix (14%). The most common histologic types of radiation-associated sarcoma were osteogenic (21 %), malignant fibrous histiocytoma (16%), and angiosarcoma/lymphangiosarcoma (15%). Most of the tumors were high grade (87%). Three variables had prognostic significance in multivariate analysis: the presence of metastatic disease, the completeness of operative resection in patients with localized disease, and the size of the primary tumor in patients who underwent complete resection of the sarcoma. Survival was independent of histologic subtype or site of disease. © 1992, American Medical Association. All rights reserved. |
| Keywords: | osteosarcoma; adolescent; adult; child; preschool child; school child; aged; aged, 80 and over; bone neoplasms; child, preschool; survival analysis; major clinical study; histopathology; cancer localization; cancer risk; conference paper; cancer radiotherapy; follow-up studies; cancer incidence; breast cancer; incidence; breast neoplasms; sarcoma; infant; neoplasms, radiation-induced; lymphoma; soft tissue sarcoma; neoplasms, second primary; soft tissue neoplasms; uterine cervix carcinoma; radiation carcinogenesis; middle age; cervix neoplasms; prognosis; human; male; female; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title | Archives of Surgery |
| Volume: | 127 |
| Issue: | 12 |
| Conference Dates: | 1992 Mar 16-17 |
| Conference Location: | New York, NY |
| ISBN: | 0004-0010 |
| Publisher: | American Medical Association |
| Date Published: | 1992-12-01 |
| Start Page: | 1379 |
| End Page: | 1385 |
| Language: | English |
| DOI: | 10.1001/archsurg.1992.01420120013002 |
| PUBMED: | 1365680 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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