| Abstract: |
Over a 22-month period, we investigated optic and otic toxicity accompanying intra-arterial cisplatin therapy. Baseline and serial neurologic and ophthalmologic examinations, visual evoked potentials, and brain-stem auditory evoked potentials were performed in six patients, aged 37 to 53 years. Patients received infraophthalmic intra-arterial cisplatin (60 mg/m2) every month for three to 10 treatments (mean, six treatments). Five of the six patients had progressive optic toxicity. In two patients, the visual evoked potential prolongation preceded acuity loss by at least 4 months. Two patients had evidence of otic toxicity by either brain-stem auditory evoked potential or click threshold and brain-stem auditory evoked potential. Intra-arterial cisplatin neurotoxicity may be significant in patients with already limited survival. Visual evoked potential and brain-stem auditory evoked potential should be used to monitor patients receiving potentially neurotoxic therapy. © 1992, American Medical Association. All Rights Reserved. |
| Keywords: |
adult; clinical article; cisplatin; neurotoxicity; brain tumor; glioma; brain neoplasms; prospective studies; carmustine; intraarterial drug administration; pattern recognition, visual; ototoxicity; middle age; evoked potentials, visual; evoked visual response; optic nerve disease; human; male; female; priority journal; article; vision disorders; support, u.s. gov't, p.h.s.; evoked potentials, auditory, brain stem; evoked brain stem auditory response; hearing loss, bilateral
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