Hypocellular bladder wash specimens and their clinical significance Journal Article


Authors: Kusuda, L.; Kimmel, M.; Fair, W. R.; Melamed, M.
Article Title: Hypocellular bladder wash specimens and their clinical significance
Abstract: Bladder wash flow cytometry specimens containing less than 1,000 cells were defined as hypocellular. Between June 1981 and December 1990, 5,676 bladder wash flow cytometry specimens were collected, of which 142 (2.5%) were deemed hypocellular. Of the 132 evaluable patients with hypocellular specimens 34 (30%) had documented evidence of carcinoma compared to 52% for the entire population. Among the 34 patients 30 had transitional cell carcinoma, of which 12 were carcinoma in situ, 9 stage Ta or Tl and 9 stage T2 or greater. Thus, there was no obvious relationship between stage or grade of carcinoma versus probability of a hypocellular specimen. Differences in irrigation techniques of different urologists in the operating room using general anesthesia versus catheter and cystoscopic irrigation in the outpatient clinic are discussed as possible explanations for the hypocellular specimens.
Keywords: cytology; carcinoma; bladder neoplasms; carcinoma, transitional cell; urinary-bladder; flow-cytometry; voided urine; diagnostic-value; cancer; transitional cell neoplasms; flow cytology; acridine-orange; dna-analysis
Journal Title: Journal of Urology
Volume: 150
Issue: 4
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1993-10-01
Start Page: 1123
End Page: 1125
Language: English
ACCESSION: WOS:A1993LX76200010
DOI: 10.1016/s0022-5347(17)35704-x
PROVIDER: wos
PUBMED: 8371370
Notes: Article -- Source: Wos
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  1. William R Fair
    342 Fair
  2. Myron Melamed
    148 Melamed