Bcl-6 predicts improved prognosis in primary central nervous system lymphoma Journal Article

Authors: Levy, O.; Deangelis, L. M.; Filippa, D. A.; Panageas, K. S.; Abrey, L. E.
Article Title: Bcl-6 predicts improved prognosis in primary central nervous system lymphoma
Abstract: BACKGROUND. In systemic non-Hodgkin lymphoma (NHL), tumors that resemble germinal center B-cells are less aggressive than tumors that resemble postgerminal center B-cells. However, the value of B-cell differentiation markers in primary central nervous system lymphoma (PCNSL) is less clear. The objectives of this study were to characterize the immunophenotypes of PCNSL samples and to determine their utility in predicting clinical outcomes. METHODS. The immunohistochemical staining profile of PCNSL was determined from 66 immunocompetent patients. Then, the authors evaluated whether the expression of these proteins was associated with progression-free or overall survival. RESULTS. Only 8% of PCNSL samples were positive for the cluster designation (CD) germinal center marker CD10. Another germinal center marker, bcl-6, was positive in 47% of samples. Ninety-four percent of samples expressed significant levels of the postgerminal center marker melanoma-associated antigen (MUM-1). In univariate analyses, only bcl-6 staining had a significant effect on progression-free survival (median, 20.5 months in bcl-6-positive patients vs 10.1 months in bcl-6-negative patients; P = .02). There was a nonsignificant trend toward improved overall survival in patients who had bcl-6 expressing tumors. Older age and poorer performance status, as observed previously, were associated with reduced survival. CONCLUSIONS. Bcl-6 expression was associated with a better prognosis in patients with PCNSL. © 2007 American Cancer Society.
Keywords: immunohistochemistry; adult; cancer survival; protein expression; aged; disease-free survival; middle aged; survival rate; major clinical study; cancer growth; primary central nervous system lymphoma; tumor markers, biological; age factors; central nervous system tumor; central nervous system neoplasms; melanoma antigen 1; lymphoma; prognostic factors; immunophenotyping; protein bcl 6; univariate analysis; molecular markers; common acute lymphoblastic leukemia antigen; b-cell differentiation; proto-oncogene proteins c-bcl-6
Journal Title: Cancer
Volume: 112
Issue: 1
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2008-01-01
Start Page: 151
End Page: 156
Language: English
DOI: 10.1002/cncr.23149
PUBMED: 17999414
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 15" - "Export Date: 17 November 2011" - "CODEN: CANCA" - "Source: Scopus"
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MSK Authors
  1. Lauren E Abrey
    272 Abrey
  2. Katherine S Panageas
    327 Panageas
  3. Daniel A Filippa
    99 Filippa