Mantle cell lymphoma: Current and emerging treatment strategies and unanswered questions Journal Article


Authors: Diamond, B.; Kumar, A.
Article Title: Mantle cell lymphoma: Current and emerging treatment strategies and unanswered questions
Abstract: Mantle cell lymphoma (MCL) is biologically and clinically heterogeneous with no clear standard of care. Overexpression of cyclin D1 is a hallmark of MCL. Evolving characterization of other molecular drivers explain a variety of disease phenotypes. These molecular profiles challenge risk stratification techniques. TP53-deleted disease is associated with adverse outcomes. Frontline treatment programs include intensive chemoimmunotherapy and autologous stem cell transplantation. Minimal residual disease may change management of MCL and guide therapy. As commonly dysregulated pathways become enumerated, novel biologically targeted agents and their combinations have been developed that will increasingly replace older, more toxic, and less efficacious regimens. © 2019 Elsevier Inc.
Keywords: cytarabine; mantle cell lymphoma; minimal residual disease; risk stratification; personalized medicine; novel agents; ibrutinib
Journal Title: Hematology/Oncology Clinics of North America
Volume: 33
Issue: 4
ISSN: 0889-8588
Publisher: Elsevier Inc.  
Date Published: 2019-08-01
Start Page: 613
End Page: 626
Language: English
DOI: 10.1016/j.hoc.2019.03.002
PROVIDER: scopus
PUBMED: 31229158
DOI/URL:
Notes: Review -- Source: Scopus
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MSK Authors
  1. Anita Kumar
    60 Kumar