Stem Cell Trafficking in Tissue Development, Growth, and Disease Journal Article
| Authors: | Laird, D. J.; von Andrian, U. H.; Wagers, A. J. |
| Article Title: | Stem Cell Trafficking in Tissue Development, Growth, and Disease |
| Abstract: | Regulated movement of stem cells is critical for organogenesis during development and for homeostasis and repair in adulthood. Here we analyze the biological significance and molecular mechanisms underlying stem cell trafficking in the generation of the germline, and the generation and regeneration of blood and muscle. Comparison across organisms and lineages reveals remarkable conservation as well as specialization in homing and migration mechanisms used by mature leukocytes, adult and fetal stem cells, and cancer stem cells. In vivo trafficking underpins the successful therapeutic application of hematopoietic stem cells for bone-marrow transplant, and further elucidation of homing and migration pathways in other systems will enable broader application of stem cells for targeted cell therapy and drug delivery. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | review; nonhuman; neoplasms; animals; tissue regeneration; adult stem cells; cell lineage; stem cell; germ line; cancer stem cell; neoplasm metastasis; cell migration; cell movement; stem cells; cell therapy; blood cell; cell regeneration; hematopoietic stem cell; homeostasis; bone marrow transplantation; cell adhesion; leukocyte; tissue growth; embryonic development; cell homing; organogenesis; muscle cell; fetal stem cell |
| Journal Title: | Cell |
| Volume: | 132 |
| Issue: | 4 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2008-02-22 |
| Start Page: | 612 |
| End Page: | 630 |
| Language: | English |
| DOI: | 10.1016/j.cell.2008.01.041 |
| PUBMED: | 18295579 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 80" - "Export Date: 17 November 2011" - "CODEN: CELLB" - "Source: Scopus" |
