DLC1: A significant GAP in the cancer genome Journal Article
| Authors: | Lahoz, A.; Hall, A. |
| Article Title: | DLC1: A significant GAP in the cancer genome |
| Abstract: | Rho GTPases are believed to make important contributions to the development and progression of human cancer, but direct evidence in the form of somatic mutations analogous to those affecting Ras has been lacking. A recent study in Genes & Development by Xue and colleagues (pp. 1439-1444) now provides in vivo evidence that DLC1, a negative regulator of Rho, is a tumor suppressor gene deleted almost as frequently as p53 in common cancers such as breast, colon, and lung. © 2008 by Cold Spring Harbor Laboratory Press. |
| Keywords: | somatic mutation; gene deletion; review; cancer growth; carcinoma, hepatocellular; liver neoplasms; neoplasms; breast cancer; lung cancer; carcinogenesis; cell transformation, neoplastic; cancer inhibition; tumor suppressor gene; gene expression regulation, neoplastic; colon cancer; tumor suppressor proteins; gtpase-activating proteins; oncogene ras; rho guanine nucleotide binding protein; genes, tumor suppressor; mouse model; rnai; hcc; rhoa; dlc1; dlc1 gene |
| Journal Title: | Genes and Development |
| Volume: | 22 |
| Issue: | 13 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2008-07-01 |
| Start Page: | 1724 |
| End Page: | 1730 |
| Language: | English |
| DOI: | 10.1101/gad.1691408 |
| PUBMED: | 18593873 |
| PROVIDER: | scopus |
| PMCID: | PMC2732422 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 17 November 2011" - "CODEN: GEDEE" - "Source: Scopus" |
