The use of radiation therapy for the treatment of malignant pleural mesothelioma: Expert opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation Journal Article


Authors: Gomez, D. R.; Rimner, A.; Simone, C. B. 2nd; Cho, B. C. J.; de Perrot, M.; Adjei, A. A.; Bueno, R.; Gill, R. R.; Harpole, D. H. Jr; Hesdorffer, M.; Hirsch, F. R.; Jackson, A. A.; Pass, H. I.; Rice, D. C.; Rusch, V. W.; Tsao, A. S.; Yorke, E.; Rosenzweig, K.
Article Title: The use of radiation therapy for the treatment of malignant pleural mesothelioma: Expert opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation
Abstract: Introduction: Detailed guidelines regarding the use of radiation therapy for malignant pleural mesothelioma (MPM) are currently lacking because of the rarity of the disease, the wide spectrum of clinical presentations, and the paucity of high-level data on individual treatment approaches. Methods: In March 2017, a multidisciplinary meeting of mesothelioma experts was cosponsored by the U.S. National Cancer Institute, International Association for the Study of Lung Cancer Research, and Mesothelioma Applied Research Foundation. Among the outcomes of this conference was the foundation of detailed, multidisciplinary consensus guidelines. Results: Here we present consensus recommendations on the use of radiation therapy for MPM in three discrete scenarios: (1) hemithoracic radiation therapy to be used before or after extrapleural pneumonectomy; (2) hemithoracic radiation to be used as an adjuvant to lung-sparing procedures (i.e., without pneumonectomy); and (3) palliative radiation therapy for focal symptoms caused by the disease. We discuss appropriate simulation techniques, treatment volumes, dose fractionation regimens, and normal tissue constraints. We also assess the role of particle beam therapy, specifically, proton beam therapy, for MPM. Conclusion: The recommendations provided in this consensus statement should serve as important guidelines for developing future clinical trials of treatment approaches for MPM. © 2019 International Association for the Study of Lung Cancer
Keywords: mesothelioma; radiation therapy; treatment recommendations; consensus guidelines
Journal Title: Journal of Thoracic Oncology
Volume: 14
Issue: 7
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2019-07-01
Start Page: 1172
End Page: 1183
Language: English
DOI: 10.1016/j.jtho.2019.03.030
PUBMED: 31125736
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Valerie W Rusch
    693 Rusch
  2. Daniel R Gomez
    31 Gomez
  3. Andreas Rimner
    286 Rimner
  4. Ellen D Yorke
    333 Yorke