The endoderm: A divergent cell lineage with many commonalities Review

   


Authors: Nowotschin, S.; Hadjantonakis, A. K.; Campbell, K.
Review Title: The endoderm: A divergent cell lineage with many commonalities
Abstract: The endoderm is a progenitor tissue that, in humans, gives rise to the majority of internal organs. Over the past few decades, genetic studies have identified many of the upstream signals specifying endoderm identity in different model systems, revealing them to be divergent from invertebrates to vertebrates. However, more recent studies of the cell behaviours driving endodermal morphogenesis have revealed a surprising number of shared features, including cells undergoing epithelial-to-mesenchymal transitions (EMTs), collective cell migration, and mesenchymal-to-epithelial transitions (METs). In this Review, we highlight how cross-organismal studies of endoderm morphogenesis provide a useful perspective that can move our understanding of this fascinating tissue forward. © 2019. Published by The Company of Biologists Ltd.
Keywords: signal transduction; review; nonhuman; cell function; morphogenesis; cell lineage; cell migration; epithelium; vertebrate; mesenchyme; endoderm; epithelial mesenchymal transition; identity; collective cell migration; invertebrate; human; epithelial-to-mesenchymal transitions; mesenchymal-to-epithelial transitions
Journal Title: Development
Volume: 146
Issue: 11
ISSN: 0950-1991
Publisher: Company of Biologists  
Date Published: 2019-06-01
Start Page: dev150920
Language: English
DOI: 10.1242/dev.150920
PUBMED: 31160415
PROVIDER: scopus
PMCID: PMC6589075
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067211021&doi=10.1242%2fdev.150920&partnerID=40&md5=5bb09c45f936adfcd1b4dbcee358e941
Notes: Review -- Source: Scopus
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MSK Authors
  1. Sonja Nowotschin
    37 Nowotschin
  2. Anna-Katerina Hadjantonakis
    191 Hadjantonakis
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