Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase Conference Paper

  

Authors:	Ercikan, E.; Waltham, M.; Dicker, A.; Schweitzer, B.; Bertino, J. R.
Title:	Effect of codon 22 mutations on substrate and inhibitor binding for human dihydrofolate reductase
Conference Title:	10th International Symposium on Chemistry and Biology of Pteridines
Keywords:	controlled study; gene mutation; conference paper; comparative study; methotrexate; binding affinity; polymerase chain reaction; ph; structure activity relation; pyrimidines; amino acid sequence; kinetics; recombinant proteins; inhibition kinetics; mutagenesis, site-directed; codon; leucine; dihydrofolate reductase; folic acid antagonists; tetrahydrofolate dehydrogenase; enzyme substrate complex; aminopterin; hydrogen-ion concentration; michaelis constant; enzyme variant; human; priority journal
Journal Title	Advances in Experimental Medicine and Biology
Volume:	338
Conference Dates:	1993 Mar 21-26
Conference Location:	Orange Beach, AL
ISBN:	0065-2598
Publisher:	Springer
Date Published:	1993-01-01
Start Page:	515
End Page:	519
Language:	English
PUBMED:	8304170
PROVIDER:	scopus
DOI:	10.1007/978-1-4615-2960-6_104
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027527322&partnerID=40&md5=66b034df30c68a0173ca051b7940da8f
Notes:	Chapter in "Chemistry and Biology of Pteridines and Folates" (ISBN: 978-1-4613-6287-6) -- Source: Scopus

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