Follicular mucinosis in patients with hematologic malignancies other than mycosis fungoides: A clinicopathologic study Journal Article


Authors: Geller, S.; Gomez, C. J.; Myskowski, P. L.; Pulitzer, M.
Article Title: Follicular mucinosis in patients with hematologic malignancies other than mycosis fungoides: A clinicopathologic study
Abstract: Background: Follicular mucinosis (FM), which is defined by mucin accumulation within follicular epithelium, may occur in mycosis fungoides (MF). FM without MF is occasionally reported in systemic hematologic malignancies and may be diagnostically challenging. Objective: To describe clinicopathologic characteristics of FM in patients with hematologic malignancies other than MF. Methods: Clinical data and histopathology features were analyzed in patients with FM and hematologic malignancies diagnosed between 1994 and 2017. Results: A total of 18 patients with FM and systemic hematologic malignancies without cutaneous T-cell lymphoma (CTCL) were identified; 9 of them were discovered after hematopoietic stem cell transplantation. No patients with non–CTCL-associated FM (n = 46 [37 biopsy specimens]) developed CTCL during a mean follow-up of 4.3 years. Of the cases of CTCL associated with FM (n = 44 [31 biopsy specimens]), MF was the most common subtype (n = 38), although other CTCLs were identified. FM in patients with non-CTCL hematologic malignancies differed clinically from those with MF-associated FM, presenting most frequently with erythematous papules (P < .0001), without plaques (P <.0001), without alopecia (P = .001), and without histopathologically identified epidermal exocytosis (P = .013). Limitations: A retrospective study in a single cancer center. Conclusions: FM can present in systemic hematologic malignancies, including after hematopoietic stem cell transplantation. Papular lesional morphologic and histopathologic features may help to distinguish these cases from MF. © 2019 American Academy of Dermatology, Inc.
Keywords: histopathology; hematopoietic stem cell transplantation; cutaneous t-cell lymphoma; mycosis fungoides; ctcl; follicular mucinosis; cd30 + lymphoproliferative disorders; mf
Journal Title: Journal of the American Academy of Dermatology
Volume: 80
Issue: 6
ISSN: 0190-9622
Publisher: Mosby Elsevier  
Date Published: 2019-06-01
Start Page: 1704
End Page: 1711
Language: English
DOI: 10.1016/j.jaad.2019.01.062
PUBMED: 30716405
PROVIDER: scopus
PMCID: PMC6526060
DOI/URL:
Notes: Article -- Export Date: 3 June 2019 -- Source: Scopus
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  1. Melissa P Pulitzer
    203 Pulitzer
  2. Shamir Geller
    53 Geller
  3. Christian J Gomez
    2 Gomez