A phase 2 trial of oral imatinib in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma in second or greater remission Journal Article
| Authors: | Juretzka, M.; Hensley, M. L.; Tew, W.; Konner, J.; Aghajanian, C.; Leitao, M.; Iasonos, A.; Soslow, R.; Park, K.; Sabbatini, P. |
| Article Title: | A phase 2 trial of oral imatinib in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma in second or greater remission |
| Abstract: | Purpose of investigation: To determine the effect of imatinib on progression-free survival in patients with epithelial ovarian cancer in second or greater complete clinical remission (CCR). Methods: 35 patients were enrolled between 10/2002 and 1/2005. Eligible patients received imatinib at 400 mg daily orally. Results: One patient withdrew consent, and two patients received protocol therapy in first remission and were excluded. Five patients were removed for possibly related toxicity. No associations were seen between PDGF-R staining and PFS. Conclusions: Treatment with imatinib for patients with ovarian cancer in second CCR or greater did not prolong the PFS beyond the historical estimate. |
| Keywords: | immunohistochemistry; adult; clinical article; human tissue; aged; disease-free survival; middle aged; clinical trial; fatigue; neutropenia; diarrhea; drug withdrawal; side effect; disease free survival; ovarian cancer; cytoreductive surgery; ovarian neoplasms; imatinib; drug eruption; ovary cancer; peritoneum cancer; phase 2 clinical trial; neoplasm recurrence, local; peritoneal neoplasms; anemia; nausea; neuropathy; thrombocytopenia; vomiting; creatinine blood level; platelet derived growth factor receptor; pyrimidines; abdominal pain; hyperglycemia; hypomagnesemia; protein kinase inhibitors; hypokalemia; cancer regression; remission; piperazines; platinum complex; taxane derivative; uterine tube carcinoma; fallopian tube neoplasms; administration, oral; dry eye; cellulitis; neoplasms, glandular and epithelial; petechia; peritoneal; ureter stone |
| Journal Title: | European Journal of Gynaecological Oncology |
| Volume: | 29 |
| Issue: | 6 |
| ISSN: | 0392-2936 |
| Publisher: | I R O G Canada, Inc |
| Date Published: | 2008-01-01 |
| Start Page: | 568 |
| End Page: | 572 |
| Language: | English |
| PUBMED: | 19115680 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: EJGOD" - "Source: Scopus" |
