Romiplostim for immune thrombocytopenia in neuroblastoma patients receiving chemotherapy Journal Article
| Authors: | Fassel, H.; Bussel, J. B.; Roberts, S. S.; Modak, S. |
| Article Title: | Romiplostim for immune thrombocytopenia in neuroblastoma patients receiving chemotherapy |
| Abstract: | Thrombocytopenia, a serious complication of myelosuppressive chemotherapy in cancer patients, is managed with platelet transfusions until recovery of platelet counts. However, children receiving chemotherapy can rarely develop immune thrombocytopenia (ITP) that is refractory to transfused platelets. This limits the ability to achieve adequate platelet counts and administer further myelosuppressive chemotherapy safely, especially if first-line ITP therapy is ineffective. We report 2 cases of intravenous immunoglobulin refractory ITP in children receiving chemotherapy for high-risk neuroblastoma. ITP was successfully treated with the thrombopoietin-receptor-agonist romiplostim, allowing safe and timely continuation of antineuroblastoma therapies in these high-risk patients. © 2018 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; child; clinical article; preschool child; leukemia; unclassified drug; human cell; case report; cisplatin; doxorubicin; cancer radiotherapy; rituximab; temozolomide; topotecan; drug megadose; gene; carboplatin; etoposide; thrombocytopenia; granulocyte macrophage colony stimulating factor; camptothecin; cyclophosphamide; vincristine; ifosfamide; irinotecan; monoclonal antibody; cancer regression; neuroblastoma; drug response; (3 iodobenzyl)guanidine; romiplostim; idiopathic thrombocytopenic purpura; platelet; megakaryocyte; glycoprotein; monoclonal antibody 3f8; platelet count; ecchymosis; glycoprotein iib; thrombopoietin; petechia; gingiva bleeding; mycn gene; cancer; human; male; female; priority journal; article; palbociclib; glycoprotein ib; glycoprotein iiia; glycoprotein ix |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 41 |
| Issue: | 4 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2019-05-01 |
| Start Page: | e257 |
| End Page: | e259 |
| Language: | English |
| DOI: | 10.1097/mph.0000000000001187 |
| PUBMED: | 29683946 |
| PROVIDER: | scopus |
| PMCID: | PMC6195864 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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