Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1 Journal Article
| Authors: | Hunder, N. N.; Wallen, H.; Cao, J.; Hendricks, D. W.; Reilly, J. Z.; Rodmyre, R.; Jungbluth, A.; Gnjatic, S.; Thompson, J. A.; Yee, C. |
| Article Title: | Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1 |
| Abstract: | We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1. Copyright © 2008 Massachusetts Medical Society. |
| Keywords: | adult; human tissue; middle aged; human cell; case report; alpha interferon; drug megadose; interleukin 2; melanoma; membrane proteins; cancer regression; immune response; immunotherapy; antigens, neoplasm; immunoglobulin g; ny eso 1 antigen; cd4+ t lymphocyte; cd4-positive t-lymphocytes; cell isolation; remission induction; cytokine release; antibodies, neoplasm; cell expansion; antibody titer |
| Journal Title: | New England Journal of Medicine |
| Volume: | 358 |
| Issue: | 25 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 2008-06-19 |
| Start Page: | 2698 |
| End Page: | 2703 |
| Language: | English |
| DOI: | 10.1056/NEJMoa0800251 |
| PUBMED: | 18565862 |
| PROVIDER: | scopus |
| PMCID: | PMC3277288 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 186" - "Export Date: 17 November 2011" - "CODEN: NEJMA" - "Source: Scopus" |
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