Strain-relatedness of methicillin-resistant Staphylococcus aureus isolates recovered from patients with repeated infection Journal Article

   


Authors: Huang, S. S.; Diekema, D. J.; Warren, D. K.; Zuccotti, G.; Winokur, P. L.; Tendolkar, S.; Boyken, L.; Datta, R.; Jones, R. M.; Ward, M. A.; Aubrey, T.; Onderdonk, A. B.; Garcia, C.; Platt, R.
Article Title: Strain-relatedness of methicillin-resistant Staphylococcus aureus isolates recovered from patients with repeated infection
Abstract: Invasive disease following methicillin-resistant Staphylococcus aureus (MRSA) detection is common, regardless of whether initial detection involves colonization or infection. We assessed the genetic relatedness of isolates obtained ≥2 weeks apart representing either repeated infections or colonization-infection sets to determine if infections are likely to be caused by previously harbored strains. We found that MRSA infection following initial colonization or infection is caused by the same strain in most cases, suggesting that a single successful attempt at decolonization may prevent the majority of later infection. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Keywords: adolescent; adult; aged; aged, 80 and over; middle aged; major clinical study; clinical trial; cohort studies; bacterial strain; antibiotic resistance; multicenter study; bacterium isolate; bacteremia; gentamicin; methicillin resistance; staphylococcus aureus; bacterial colonization; methicillin resistant staphylococcus aureus; staphylococcal infections; linezolid; vancomycin; tetracycline; cotrimoxazole; pseudomonic acid; rifampicin; electrophoresis, gel, pulsed-field; erythromycin; moxifloxacin; phylogeny; molecular phylogeny; clindamycin; oxacillin; dalfopristin; quinupristin
Journal Title: Clinical Infectious Diseases
Volume: 46
Issue: 8
ISSN: 1058-4838
Publisher: Oxford University Press  
Date Published: 2008-04-15
Start Page: 1241
End Page: 1247
Language: English
DOI: 10.1086/529381
PUBMED: 18444862
PROVIDER: scopus
PMCID: PMC2723744
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-42549148582&partnerID=40&md5=dfe15d690ff2b83604f8a9a52039de2a
Notes: --- - "Cited By (since 1996): 18" - "Export Date: 17 November 2011" - "CODEN: CIDIE" - "Source: Scopus"
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MSK Authors
  1. Tanya Aubrey
    2 Aubrey
  2. Gianna Zuccotti
    13 Zuccotti
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