Three-fraction accelerated partial breast irradiation (APBI) delivered with brachytherapy applicators is feasible and safe: First results from the TRIUMPH-T trial Journal Article
| Authors: | Khan, A. J.; Chen, P. Y.; Yashar, C.; Poppe, M. M.; Li, L.; Yehia, Z. A.; Vicini, F. A.; Moore, D.; Dale, R.; Arthur, D.; Shah, C.; Haffty, B. G.; Kuske, R. |
| Article Title: | Three-fraction accelerated partial breast irradiation (APBI) delivered with brachytherapy applicators is feasible and safe: First results from the TRIUMPH-T trial |
| Abstract: | Purpose: Shorter courses of accelerated partial-breast irradiation delivered as single-fraction intraoperative therapy are now offered as an alternative to 4 to 6 weeks of whole-breast irradiation after lumpectomy. However, this approach has potential shortcomings in patient selection and target volume definition and in dosimetric, radiobiological, and logistical issues. We designed a prospective, phase 2, multi-institution clinical trial to study 2- or 3-day accelerated partial breast irradiation delivered with brachytherapy applicators. Methods and Materials: This trial treats select breast cancers after breast-conserving surgery with brachytherapy applicators that deliver 22.5 Gy in 3 fractions of 7.5 Gy. The planning treatment volume was 1 to 1.5 cm beyond the surgical cavity. Eligible women were aged ≥45 years with unicentric invasive or in situ tumors ≤3.0 cm with positive estrogen or progesterone receptors and no metastasis to axillary nodes that have been excised with negative margins. Strict dosimetric parameters were required to be met before acceptance into the trial. Results: A group of 200 patients was prospectively enrolled and followed for a minimum of 6 months. Two- or 3-day brachytherapy was associated with low acute or subacute toxicity, 97.25% excellent or good cosmetic outcomes, and excellent local control in select breast cancers. Conclusions: Ultrashort breast brachytherapy is dosimetrically feasible and can be delivered with excellent short-term tolerance and low toxicity. © 2019 Elsevier Inc. |
| Keywords: | adult; treatment outcome; antibiotic agent; antibiotic therapy; major clinical study; clinical feature; cancer recurrence; treatment duration; bone metastasis; radiation dose; follow up; prospective study; phase 2 clinical trial; breast cancer; radiotherapy; oncology; dosimetry; breast carcinoma; partial mastectomy; irradiation; erythema; hyperpigmentation; brachytherapy; surgery; estrogen receptor; progesterone receptor; toxicity; seroma; mastitis; giant cell; diseases; radiation dermatitis; breast conserving surgery; accelerated partial breast irradiation; mastalgia; fat necrosis; dosimetric parameter; surgical wound; whole-breast irradiation; treatment volumes; methods and materials; human; female; priority journal; article; applicators; single fractions; pustular psoriasis |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 104 |
| Issue: | 1 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2019-05-01 |
| Start Page: | 67 |
| End Page: | 74 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2018.12.050 |
| PUBMED: | 30611839 |
| PROVIDER: | scopus |
| PMCID: | PMC7373303 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 May 2019 -- Source: Scopus |
