Postoperative intensity-modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity Journal Article
| Authors: | Hoppe, B. S.; Wolden, S. L.; Zelefsky, M. J.; Mechalakos, J. G.; Shah, J. P.; Kraus, D. H.; Lee, N. |
| Article Title: | Postoperative intensity-modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: Technique, early outcomes, and toxicity |
| Abstract: | Background. Our aim was to review Memorial Sloan-Kettering Cancer Center's experience with postoperative intensity-modulated radiotherapy (IMRT) for paranasal sinus, nasal cavity, and lacrimal gland cancer and report dosimetric measures, toxicity, and outcomes. Methods. Between September 2000 and June 2006, 37 patients with paranasal sinus, nasal cavity, or lacrimal gland cancer underwent postoperative IMRT. Median values were as follows: prescription dose, 60 Gy (range, 50-70); PTVD95, 99% (range, 79-101%); optic nerve Dmax, 53 Gy (range, 2-54); optic chiasm Dmax, 51 Gy (range, 2-55). Acute and late toxicities were scored by Radiation Therapy Oncology Group morbidity criteria. Results. Median follow-up was 28 months. Two-year local progression-free and overall survivals were 75% and 80%. No early- or late-grade 3/4 radiation-induced ophthalmologic toxicity occurred. Conclusions. Preliminary results show that adjuvant IMRT in these patients is feasible, allowed for excellent planning target volume (PTV) coverage, and minimized dose delivered to optic structures. Longer follow-up is warranted to assess the extent of late effects and outcomes. ©2008 Wiley Periodicals, Inc. |
| Keywords: | adolescent; adult; cancer chemotherapy; clinical article; treatment outcome; treatment response; aged; middle aged; survival analysis; cancer surgery; survival rate; retrospective studies; overall survival; intensity modulated radiation therapy; cancer growth; treatment planning; cancer adjuvant therapy; cancer patient; cancer radiotherapy; disease free survival; postoperative care; radiation dose; radiotherapy, adjuvant; cancer staging; follow up; follow-up studies; antineoplastic agent; cancer grading; radiotherapy dosage; radiotherapy; morbidity; radiation injury; risk assessment; kaplan-meiers estimate; survival time; imrt; radiotherapy, intensity-modulated; dosimetry; probability; fluorodeoxyglucose f 18; computer assisted emission tomography; radiation injuries; therapy effect; radiotherapy planning, computer-assisted; paranasal sinus cancer; paranasal sinus neoplasms; paranasal sinus; nose neoplasms; nasal cavity; eye neoplasms; lacrimal gland; lacrimal gland tumor; nose cavity cancer; lacrimal apparatus |
| Journal Title: | Head & Neck |
| Volume: | 30 |
| Issue: | 7 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2008-07-01 |
| Start Page: | 925 |
| End Page: | 932 |
| Language: | English |
| DOI: | 10.1002/hed.20800 |
| PUBMED: | 18302261 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: HEANE" - "Source: Scopus" |
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