Cancer stem cells and survival pathways Journal Article
| Authors: | Hambardzumyan, D.; Becher, O. J.; Holland, E. C. |
| Article Title: | Cancer stem cells and survival pathways |
| Abstract: | Gliomas and medulloblastomas are the most frequent malignant brain tumors in adult and children respectively. Although both tumors arise in the CNS, there is a significant difference in their therapeutic response. Medulloblastomas are relatively curable, while glioblastomas are basically incurable. During the last decade several reports have demonstrated the existence of cancer stem cells in brain tumors, their location and their response to treatment. We have recently described the therapeutic response of medulloblastomas to radiation in their native microenvironment, illustrating how the p53 and Pi3K signaling pathways lead to the evasion of cell death by the nestin-expressing cells in the perivascular stem cell niche, even while the bulk of the tumor succumbs to apoptosis.1 It remains to be determined whether this mechanism of tumor resistance applies to the more complex stem-cell niche and tumor bulk of gliomas. ©2008 Landes Bioscience. |
| Keywords: | signal transduction; protein expression; review; nonhuman; cancer radiotherapy; glioma; brain neoplasms; mouse; animals; mice; cell survival; apoptosis; models, biological; animal model; nerve tissue proteins; neural stem cell; phosphatidylinositol 3 kinase; protein p53; cancer resistance; neoplastic stem cells; receptors, notch; medulloblastoma; cancer stem cell; 1-phosphatidylinositol 3-kinase; tumor suppressor protein p53; stem cells; mouse models; nestin; intermediate filament proteins; pi3k pathway |
| Journal Title: | Cell Cycle |
| Volume: | 7 |
| Issue: | 10 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2008-01-01 |
| Start Page: | 1371 |
| End Page: | 1378 |
| Language: | English |
| PUBMED: | 18421251 |
| PROVIDER: | scopus |
| DOI: | 10.4161/cc.7.10.5954 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 36" - "Export Date: 17 November 2011" - "Source: Scopus" |
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