Photoimmunoconjugates: Novel synthetic strategies to target and treat cancer by photodynamic therapy Journal Article


Authors: Fernandes, S. R. G.; Fernandes, R.; Sarmento, B.; Pereira, P. M. R.; Tomé, J. P. C.
Article Title: Photoimmunoconjugates: Novel synthetic strategies to target and treat cancer by photodynamic therapy
Abstract: Photodynamic therapy (PDT) combines a photosensitizer (PS) with the physical energy of non-ionizing light to trigger cell death pathways. PDT has potential as a therapeutic modality to be used in alternative or in combination with other conventional cancer treatment protocols (e.g. surgery, chemotherapy and radiotherapy). Still, due to the lack of specificity of the current PSs to target the tumor cells, several studies have exploited their conjugation with targeting moieties. PSs conjugated with antibodies (Abs) or their fragments, able to bind antigens overexpressed in the tumors, have demonstrated potential in PDT of tumors. This review provides an overview of the most recent advances on photoimmunoconjugates (PICs) for cancer PDT, which involve the first and second-generation PSs conjugated to Abs. This is an update of our previous review “Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications”, published in 2015 in Org. Biomol. Chem. © The Royal Society of Chemistry.
Journal Title: Organic & Biomolecular Chemistry
Volume: 17
Issue: 10
ISSN: 1477-0520
Publisher: Royal Society of Chemistry  
Date Published: 2019-03-14
Start Page: 2579
End Page: 2593
Language: English
DOI: 10.1039/c8ob02902d
PUBMED: 30648722
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 1 April 2019 -- Source: Scopus
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