The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: A consensus statement from the International Myeloma Working Group (IMWG) Journal Article


Authors: Kyriakou, C.; Molloy, S.; Vrionis, F.; Alberico, R.; Bastian, L.; Zonder, J. A.; Giralt, S.; Raje, N.; Kyle, R. A.; Roodman, D. G. D.; Dimopoulos, M. A.; Rajkumar, S. V.; Durie, B. B. G.; Terpos, E.
Article Title: The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: A consensus statement from the International Myeloma Working Group (IMWG)
Abstract: Multiple myeloma (MM) represents approximately 15% of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse spinal osteolysis may result in significant morbidity by causing painful progressive vertebral compression fractures (VCFs) and deformities. Advances in the systemic treatment of myeloma have achieved high response rates and prolonged the survival significantly. Early diagnosis and management of skeletal events contribute to improving the prognosis and quality of life of MM patients. The management of patients with significant pain due to VCFs in the acute phase is not standardised. While some patients are successfully treated conservatively, and pain relief is achieved within a few weeks, a large percentage has disabling pain and morbidity and hence they are considered for surgical intervention. Balloon kyphoplasty and percutaneous vertebroplasty are minimally invasive procedures which have been shown to relieve pain and restore function. Despite increasing positive evidence for the use of these procedures, the indications, timing, efficacy, safety and their role in the treatment algorithm of myeloma spinal disease are yet to be elucidated. This paper reports an update of the consensus statement from the International Myeloma Working Group on the role of cement augmentation in myeloma patients with VCFs. © 2019, The Author(s).
Journal Title: Blood Cancer Journal
Volume: 9
Issue: 3
ISSN: 2044-5385
Publisher: Nature Publishing Group  
Date Published: 2019-02-26
Start Page: 27
Language: English
DOI: 10.1038/s41408-019-0187-7
PUBMED: 30808868
PROVIDER: scopus
PMCID: PMC6391474
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Sergio Andres Giralt
    535 Giralt