Ovarian cancer from anatomy to functional imaging Journal Article

Authors: Nougaret, S.; Vargas, H. A.; Horta, M.; Lakhman, Y.; Sala, E.
Article Title: Ovarian cancer from anatomy to functional imaging
Abstract: Ovarian carcinoma is the most common cause of death from a gynecologic malignancy with more than 2/3 of patients having peritoneal involvement at the time of diagnosis. Treatment is principally dependent on stage and extent of disease and center expertise. Patients with advanced disease are treated either by primary cytoreductive surgery (debulking) followed by adjuvant chemotherapy, or neoadjuvant chemotherapy prior to debulking surgery. Imaging at the time of initial presentation has become critical in the selection of patients who may benefit from neoadjuvant chemotherapy instead of primary debulking surgery. Moreover, with the development of neoadjuvant treatment and molecularly targeted drug, evaluation of treatment response has becoming both critical and challenging. Indeed, evaluating early tumor changes, for example, relies more on functional (assessment of tumor vascularity, necrosis, etc.) rather than macroscopic changes in tumor size. This highlights a need for novel non-invasive biomarkers to allow implementation of personalized treatment. Thus, in this review, we focus on the advances of imaging in the diagnosis and management of ovarian cancer including functional imaging and radiogenomics. © 2015, Springer Science+Business Media New York.
Keywords: cancer chemotherapy; treatment response; overall survival; histopathology; review; nuclear magnetic resonance imaging; follow up; diagnostic accuracy; computer assisted tomography; ovary cancer; tumor volume; hematologic malignancy; contrast enhancement; tumor recurrence; echography; fluorodeoxyglucose f 18; computer assisted emission tomography; ovary carcinoma; ovarian carcinoma; false positive result; diffusion weighted imaging; epithelium tumor; gynecologic malignancy; diagnostic test accuracy study; whole body mri; human; priority journal; urogenital imaging
Journal Title: Current Radiology Reports
Volume: 3
Issue: 11
ISSN: 2167-4825
Publisher: Springer  
Date Published: 2015-11-01
Start Page: 43
Language: English
DOI: 10.1007/s40134-015-0125-9
PROVIDER: scopus
Notes: Review -- Export Date: 1 April 2019 -- Source: Scopus
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MSK Authors
  1. Yuliya Lakhman
    34 Lakhman
  2. Evis Sala
    95 Sala