Desmoplastic small cell tumor with multi-phenotypic differentiation Journal Article
| Authors: | Gerald, W. L.; Rosai, J. |
| Article Title: | Desmoplastic small cell tumor with multi-phenotypic differentiation |
| Abstract: | Desmoplastic small cell tumor (DSCT) is a distinctive, poorly understood malignant tumor with a complex phenotype. The main features of the 46 cases presented here include a mean age of 20.8 years (range 7-48), male predominance (37 M:9 F), primary intraabdominal location (except for 2 cases), characteristic histologic pattern consisting of tumor cell nests surrounded by a cellular desmoplastic stroma, immunohistochemical reactivity for markers of epithelial, muscle and neural differentiation, and association with a unique cytogenetic abnormality. These findings suggest that this tumor is a distinct neoplastic process and that it probably belongs to the family of primitive small round cell developmental tumors. It is proposed that DSCT arises during development from a progenitor cell with potential for multiphenotypic differentiation. |
| Keywords: | immunohistochemistry; adolescent; adult; child; middle aged; gene translocation; genetics; comparative study; phenotype; tumor markers, biological; age factors; cell differentiation; pathology; tumor marker; age; translocation, genetic; sex difference; sex factors; chromosome 11; chromosomes, human, pair 11; ultrastructure; small cell carcinoma; carcinoma, small cell; chromosome 22; chromosomes, human, pair 22; humans; human; male; female; article |
| Journal Title: | Zentralblatt für Pathologie |
| Volume: | 139 |
| Issue: | 2 |
| ISSN: | 0863-4106 |
| Publisher: | Gustav Fischer Verlag |
| Date Published: | 1993-06-01 |
| Start Page: | 141 |
| End Page: | 151 |
| Language: | English |
| PUBMED: | 8396418 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
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