GM‐CSF as an adjunct to autologous bone marrow transplantation Journal Article

  


Authors: Gulati, S.; Bennett, C.; Phillips, J.; Van‐Poznak, C.
Article Title: GM‐CSF as an adjunct to autologous bone marrow transplantation
Abstract: Patients with cancer can now benefit from intensive drug dosage. Intensive drug dosage has become more effective because of the availability of better anti‐emetics, hematopoietic growth factors such as granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), granulocyte CSF (G‐CSF), erythropoie‐tin, etc. and improvements in hematopoietic stem cell transplantation. We have evaluated the clinical and cost effectiveness of GM‐CSF in patients undergoing autologous bone marrow transplantation (AuBMT) for Hodgkin's disease. Administration of GM‐CSF after AuBMT enhances myeloid and platelet recovery and is cost effective in the treatment of patients with relapsed Hodgkin's disease who received intensive chemotherapy and AuBMT. We also describe the use of various new therapeutic approaches with emphasis on clinical and cost benefit Further work is needed to improve the route and duration of growth factor(s) infusion and the timing of the various treatments. Copyright © 1993 AlphaMed Press
Keywords: adolescent; adult; cancer chemotherapy; cancer survival; clinical article; review; antineoplastic agents; combined modality therapy; thrombocyte; erythropoietin; cytotoxicity; hodgkin disease; cost effectiveness analysis; whole body radiation; hematopoietic stem cell; bone marrow transplantation; double-blind method; granulocyte colony stimulating factor; transplantation, autologous; recombinant granulocyte macrophage colony stimulating factor; cost benefit analysis; costs and cost analysis; autologous bone marrow transplantation; granulocyte-macrophage colony-stimulating factor; human; male; female
Journal Title: Stem Cells
Volume: 11
Issue: 1
ISSN: 1066-5099
Publisher: AlphaMed Press  
Date Published: 1993-01-01
Start Page: 20
End Page: 25
Language: English
DOI: 10.1002/stem.5530110105
PUBMED: 8457776
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027414326&doi=10.1002%2fstem.5530110105&partnerID=40&md5=b3c21c9e791263ad854440323cab2d74
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Catherine H Van Poznak
    52 Van Poznak
  2. Subhash C. Gulati
    129 Gulati
Related MSK Work