Relationship between saliva and serum CA 125 in women with and without epithelial ovarian cancer Journal Article
| Authors: | Plante, M.; Wong, G. Y.; Nisselbaum, J. S.; Almadrones, L.; Hoskins, W. J.; Rubin, S. C. |
| Article Title: | Relationship between saliva and serum CA 125 in women with and without epithelial ovarian cancer |
| Abstract: | Objective: To determine the distribution of saliva CA 125 levels in women with and without ovarian cancer, and to determine whether there is a correlation between saliva and serum CA 125 levels in either group. Methods: CA 125 levels were measured by immunoradiometric assay in the serum and saliva of 50 women with epithelial ovarian cancer known to have elevated serum CA 125 levels (above 35 U/mL) and in 50 women seen for benign gynecologic conditions. Results: Serum and saliva CA 125 values followed a log-normal distribution in both groups. The medians for serum and saliva CA 125 levels in cancer patients were 578 and 1379 U/mL, respectively. In the benign group, the median CA 125 value was 11 U/mL in serum and 994 U/mL in saliva. The correlation between saliva and serum CA 125 levels was not statistically significant in either the cancer (r = 0.003) or the benign group (r = 0.025). Conclusion: There is no relationship between saliva and serum CA 125 levels in women with either epithelial ovarian cancer or benign gynecologic conditions. © 1993 by The American College of Obstetricians and Gynecologists. |
| Keywords: | adult; controlled study; aged; major clinical study; cancer diagnosis; prospective studies; ovarian neoplasms; ovary cancer; diagnostic value; blood analysis; ca 125 antigen; antigens, tumor-associated, carbohydrate; saliva analysis; middle age; radioimmunoassay; saliva; genital diseases, female; human; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; immunoradiometric assay |
| Journal Title: | Obstetrics and Gynecology |
| Volume: | 81 |
| Issue: | 6 |
| ISSN: | 0029-7844 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1993-06-01 |
| Start Page: | 989 |
| End Page: | 992 |
| Language: | English |
| PUBMED: | 8497368 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
