Possibility for the existence of a general conformational motif in the active sites of enzymes which are involved in nucleic acids metabolism Journal Article


Authors: Krayevsky, A. A.; Watanabe, K. A.
Article Title: Possibility for the existence of a general conformational motif in the active sites of enzymes which are involved in nucleic acids metabolism
Abstract: Many different modified nucleosides and nucleotides with conformationally restricted partly flattened sugar residues are analyzed as substrates or inhibitors of several groups of enzymes of nucleic acid metabolism. A detailed examination of the sugar moiety of large group of modified nucleosides showed that there is a striking conformational similarity, i. e., they are flattened. We propose herein a hypothesis which can represent a general conformational elements in the structure of the active sites of several different groups of enzymes. This proposal envisions that during the enzymatic process natural substrates should reflect these flattened conformations. This hypothesis allows computation of conformational analyses of the enzyme actives centers as well as the design of new actively metabolized modified nucleosides. © 1993, Taylor & Francis Group, LLC. All rights reserved.
Keywords: nucleoside; enzyme active site; nucleic acid metabolism; enzyme conformation; article
Journal Title: Nucleosides & Nucleotides
Volume: 12
Issue: 6
ISSN: 0732-8311
Publisher: Taylor & Francis Inc.  
Date Published: 1993-07-01
Start Page: 649
End Page: 670
Language: English
DOI: 10.1080/07328319308019019
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Kyoichi A Watanabe
    125 Watanabe