The neuronal nuclear antigen recognized by the human anti-Ri autoantibody is expressed in central but not peripheral nervous system neurons Journal Article

  

Authors:	Graus, F.; Rowe, G.; Fueyo, J.; Darnell, R. B.; Dalmau, J.
Article Title:	The neuronal nuclear antigen recognized by the human anti-Ri autoantibody is expressed in central but not peripheral nervous system neurons
Abstract:	Anti-Ri is a human autoantibody that recognizes a neuronal nuclear antigen (Ri). Biotinylated IgG from serum of two patients with high titers of anti-Ri antibodies was used to study the distribution of the Ri antigen in a panel of normal human tissues. the expression of the Ri antigen was evaluated by an avidin-biotin peroxidase technique and comfirmed by immunoblotting. The Ri antigen was restricted to the neurons of the central nervous system (CNS) and some pituitary cells. Most neurons in dorsal root, Gasserian and sympathetic ganglia, and myenteric plexus were negative or, a few of them, very weakly positive. The functional implication of the different expression of the Ri antigen between neurons of the central and peripheral nervous system is presently unknown. © 1993.
Keywords:	immunohistochemistry; controlled study; human tissue; neurons; central nervous system; immunoenzyme techniques; antigens; immunoglobulin g; iodine radioisotopes; immunoblotting; autoimmunity; cell nucleus; peripheral nerves; autoantibody; paraneoplastic syndrome; nerve cell; autoantibodies; biotin; spinal ganglion; ganglia, sympathetic; ganglia, spinal; paraneoplastic disease; myenteric plexus; human; priority journal; article; support, non-u.s. gov't; neuronal antigen
Journal Title:	Neuroscience Letters
Volume:	150
Issue:	2
ISSN:	0304-3940
Publisher:	Elsevier Science, Inc.
Date Published:	1993-02-19
Start Page:	212
End Page:	214
Language:	English
DOI:	10.1016/0304-3940(93)90538-v
PUBMED:	8469424
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027266857&doi=10.1016%2f0304-3940%2893%2990538-V&partnerID=40&md5=a0d86a182d002aee9aa2e2ab90b10611
Notes:	Article -- Export Date: 1 March 2019 -- Source: Scopus

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