Characterization of neuroblastoma xenograft in rat flank. I. Growth, interstitial fluid pressure, and interstitial fluid velocity distribution profiles Journal Article

  

Authors:	DiResta, G. R.; Lee, J.; Larson, S. M.; Arbit, E.
Article Title:	Characterization of neuroblastoma xenograft in rat flank. I. Growth, interstitial fluid pressure, and interstitial fluid velocity distribution profiles
Abstract:	The growth, interstitial fluid pressure (IFP) and interstitial fluid velocity (IFV) profiles of a human neuroblastoma propagated in the flank of an immune suppressed rat were characterized. IFP was measured in the tumor center as a function of size, while radial distributions of IFP and IFV were measured in 2-cm tumors. IFP and IFV were measured using the wick-in-needle and clearance of locally generated hydrogen techniques, respectively. These techniques have a high spatial resolution, permit repetitive measurements, and are minimally invasive. We observed that IFP in the neuroblastoma increased as the tumor grew. Furthermore, IFP increased and its IFV decreased from the periphery toward the center of the tumor. Measured IFP and IFV values were compared to theoretical expectations calculated from the Baxter and Jain mathematical model. The predictions were highly correlated to the measured IFP and IFV profiles with the transport impedence parameter α2 = 24.4. From our measurement data and the Baxter-Jain equations, we computed the interstitium hydraulic conductivity for neuroblastoma to be 7.11 × 10-6 cm2/mm Hg-sec. © 1993 Academic Press, Inc.
Keywords:	controlled study; cancer growth; nonhuman; animal; animal tissue; cell division; animal model; tumor xenograft; kinetics; tissue distribution; neuroblastoma; rat; transplantation, heterologous; rats; rats, nude; neoplasm transplantation; pressure; tissue pressure; biological transport; extracellular space; hip; rheology; male; priority journal; article; support, u.s. gov't, non-p.h.s.
Journal Title:	Microvascular Research
Volume:	46
Issue:	2
ISSN:	0026-2862
Publisher:	Elsevier Inc.
Date Published:	1993-09-01
Start Page:	158
End Page:	177
Language:	English
DOI:	10.1006/mvre.1993.1044
PUBMED:	8246816
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027482236&doi=10.1006%2fmvre.1993.1044&partnerID=40&md5=cb904aaa19f25a7ffddc465f4146255c
Notes:	Article -- Export Date: 1 March 2019 -- Source: Scopus

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