Second-line management of metastatic colorectal cancer Journal Article
| Authors: | Gallagher, D. J.; Kemeny, N. |
| Article Title: | Second-line management of metastatic colorectal cancer |
| Abstract: | The treatment of colorectal cancer has increased in complexity in recent years, with patients now receiving many lines of treatment. Standard first-line therapy has evolved with biologic agents used frequently in first-line settings. However, data are lacking to guide treatment decisions upon progression. Now that more is known about the toxicities of commonly used agents, such as irinotecan and oxaliplatin, stop-and-go strategies have been explored to decrease toxicities. The importance of resecting disease and decreasing tumor burden is recognized and there is some ability to get to resection even after second-line therapy. Local therapies, such as hepatic arterial infusion chemotherapy, have allowed a select group of patients to be approached with curative intent. This article reviews treatment options after progression on irinotecan- or oxaliplatin-based first-line therapy and highlights some of the difficulties encountered when interpreting data. |
| Keywords: | cancer chemotherapy; unclassified drug; clinical trial; review; salvage therapy; bevacizumab; cisplatin; erlotinib; fluorouracil; placebo; drug withdrawal; clinical trials as topic; capecitabine; gemcitabine; combined modality therapy; neurotoxicity; antineoplastic agent; colorectal cancer; liver toxicity; multiple cycle treatment; epidermal growth factor receptor; dexamethasone; angiogenesis; cetuximab; carmustine; irinotecan; panitumumab; colorectal neoplasms; liver metastasis; folinic acid; gefitinib; drug infusion; seer program; mitomycin c; drug substitution; oxaliplatin; floxuridine; pemetrexed; lapatinib; fatty liver; steatosis; hepatic arterial infusion; folfiri; folfox; vein occlusion; vatalinib |
| Journal Title: | Clinical Colorectal Cancer |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 1533-0028 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-01-01 |
| Start Page: | 25 |
| End Page: | 32 |
| Language: | English |
| DOI: | 10.3816/CCC.2008.n.004 |
| PUBMED: | 18279574 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: CCCLC" - "Source: Scopus" |
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