1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders Journal Article
| Authors: | Gabis, L.; Huang, W.; Azizian, A.; DeVincent, C.; Tudorica, A.; Kesner-Baruch, Y.; Roche, P.; Pomeroy, J. |
| Article Title: | 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders |
| Abstract: | This study assessed metabolic functioning of regional brain areas to address whether there is a neurometabolic profile reflecting the underlying neuropathology in individuals with autism spectrum disorders, and if varied profiles correlate with the clinical subtypes. Thirteen children (7-16 years) with autism spectrum disorders and 8 typically developing children were compared on 1H-magnetic resonance spectroscopy data collected from hippocampus-amygdala and cerebellar regions. The autism spectrum disorder group had significantly lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions. Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder. Comparisons within the autism spectrum disorder group when clinically subdivided by history of speech delay revealed significant metabolic ratio differences. Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders. © 2008 Sage Publications. |
| Keywords: | adolescent; child; clinical article; controlled study; school child; case control study; case-control studies; disease classification; sensitivity and specificity; biological marker; biological markers; metabolism; cerebellum; classification; validation study; physiology; diagnostic agent; brain; diagnostic value; reference values; drug derivative; magnetic resonance spectroscopy; choline; creatine; nuclear magnetic resonance spectroscopy; cognition; protons; language; hemispheric dominance; brain mapping; functional laterality; analysis of variance; statistics, nonparametric; inositol; n acetylaspartic acid; aspartic acid; n-acetylaspartate; neuropathology; proton nuclear magnetic resonance; proton; reference value; hippocampus; amygdala; nonparametric test; language disability; brain metabolism; autism spectrum disorders; 1h-magnetic resonance spectroscopy; brain imaging; amygdaloid nucleus; autism; intelligence quotient; asperger syndrome; autistic disorder; child development disorders, pervasive |
| Journal Title: | Journal of Child Neurology |
| Volume: | 23 |
| Issue: | 7 |
| ISSN: | 0883-0738 |
| Publisher: | Sage Publications, Inc. |
| Date Published: | 2008-07-01 |
| Start Page: | 766 |
| End Page: | 774 |
| Language: | English |
| DOI: | 10.1177/0883073808315423 |
| PUBMED: | 18487520 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: JOCNE" - "Source: Scopus" |
