Neuropsychological effects of central nervous system prophylactic treatment in childhood leukemia: Methodological considerations Journal Article
| Authors: | Butler, R. W.; Copeland, D. R. |
| Article Title: | Neuropsychological effects of central nervous system prophylactic treatment in childhood leukemia: Methodological considerations |
| Abstract: | Reviewed 53 studies on the effects of centred nervous system prophylactic treatment (CNSPT) on cognition and neuropsychological functioning. CNSPT involves irradiation and/or chemotherapy directed to the brain, and is frequently administered to children who have leukemia. The effects of CNSPT on neuropsychological functioning in long-term cancer survivors remains controversial. A number of studies failed to identify any neuropsychological impact secondary to CNSPT, whereas others reported deficits that appear to be a function of CNSPT. Several methodological issues that make it difficult to draw meaningful conclusions from this research literature are identified and discussed. Specific recommendations are made for improvements in research on CNSPT in children. © 1993 Plenum Publishing Corporation. |
| Keywords: | survival; cancer chemotherapy; cancer survival; child; child, preschool; leukemia; review; research design; methodology; brain neoplasms; cancer prevention; radiotherapy; skull irradiation; age; central nervous system neoplasms; statistical analysis; infant; infant, newborn; medical research; neuropsychological tests; cognition; mental disease; behavior disorder; cognition disorders; drug therapy; gender; childhood leukemia; psychologic test; error; academic achievement; neuropsychology; human; male; female; support, non-u.s. gov't; intelligence test; cns prophylactic treatment |
| Journal Title: | Journal of Pediatric Psychology |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 0146-8693 |
| Publisher: | Oxford University Press |
| Date Published: | 1993-06-01 |
| Start Page: | 319 |
| End Page: | 338 |
| Language: | English |
| DOI: | 10.1093/jpepsy/18.3.319 |
| PUBMED: | 8340842 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
