Growth control or terminal differentiation: Endogenous production and differential activities of vitamin A metabolites in HL-60 cells Journal Article

   


Authors: Eppinger, T. M.; Buck, J.; Hämmerling, U.
Article Title: Growth control or terminal differentiation: Endogenous production and differential activities of vitamin A metabolites in HL-60 cells
Abstract: Vitamin A (retinol) is a prohormone that exerts its pleiotropic biological effects after conversion into multiple metabolites. In this report we describe the identification of three endogenous, retinolderived effector molecules, 14-hydroxy-retro-retinol (14-HRR), anhydroretinol (AR), and retinoic acid (RA) and a putative storage form of retinol, retinylesters (RE) in the human promyelocytic leukemia cell line HL-60. Exogenous application of the retinol metabolites in retinol-depleted serum-free cultures of HL-60 allowed the identification of unique cellular functions for each metabolite: 14-HRR is a growth factor for HL-60. AR is a functional antagonist of 14-HRR with growth-inhibiting activity, and RA is a potent inducer of granulocyte differentiation accompanied by growth arrest. Finally, intracellular RE serves as storage form allowing continuous production of 14-HRR when no external retinol is available. © 1993, Rockefeller University Press., All rights reserved.
Keywords: human cell; cell proliferation; cell division; cell growth; cell differentiation; tumor cells, cultured; leukemia cell; promyelocytic leukemia; drug metabolite; retinol; retinoic acid; granulocyte; in vitro; growth inhibition; vitamin a; retinoids; growth inhibitors; tretinoin; granulocytes; cell strain hl 60; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; retinol ester
Journal Title: Journal of Experimental Medicine
Volume: 178
Issue: 6
ISSN: 0022-1007
Publisher: Rockefeller University Press  
Date Published: 1993-12-01
Start Page: 1995
End Page: 2005
Language: English
DOI: 10.1084/jem.178.6.1995
PUBMED: 8245778
PROVIDER: scopus
PMCID: PMC2191271
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027489864&doi=10.1084%2fjem.178.6.1995&partnerID=40&md5=dfc74c30b12ec994e80ed680b17122b8
Notes: Article -- Export Date: 1 March 2019 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Ulrich Hammerling
    79 Hammerling
  2. Jochen Buck
    13 Buck
Related MSK Work