Harvesting bone marrow in an outpatient setting using newer anesthetic agents Journal Article
| Authors: | Thorne, A. C.; Stewart, M.; Gulati, S. C. |
| Article Title: | Harvesting bone marrow in an outpatient setting using newer anesthetic agents |
| Abstract: | Purpose: To evaluate the results of outpatient bone marrow harvest (BMH). Patients and Methods: Seventy-two adult patients with various malignancies had 79 BMH procedures performed for future autologous bone marrow transplantation (BMT) in our institution's outpatient surgical facility. All patients were evaluated and educated before the procedure. Newer anesthetic agents specifically developed to have shorter half-lives, more rapid recovery from general anesthesia, and fewer unpleasant side effects were chosen. Propofol was used for induction of anesthesia in 76 patients, the other three were induced with sodium pentothal. The blood volume removed was replaced by colloid (6% hydroxyethyl starch). Also, a new parenteral nonnarcotic pain medication, ketoroloc, was used during the last part of general anesthesia to help with expected postoperative pain in 76 patients. Results: BMH took 111 ± 24 minutes and patients were in postanesthesia care unit (PACU) for 220 ± 72 minutes before being sent home with a companion and Tylenol with codeine (acetaminophen with codeine; McNeil Pharmaceutical, Spring House, PA). PACU complications were minor and included transient mild dizziness (7.6%), vomiting (3.8%), and fever (2.6%). No life-threatening complication was observed. Only one patient was hospitalized for observation (fever) and then sent home. Seventy-five patients (94.9%) were contacted at home by the hospital nursing staff the day following the procedure. Five (6.7%) complained of nausea or vomiting, and four (5.3%) developed fever at home (temperature, 37.2 to 38.3°C). Only 36% of patients actually took oral narcotic pain medication at home. Conclusion: Autologous BMH (AuBMH) is a safe out-patient procedure with minimal side effects when newer anesthetic agents are used. © 1993 by American Society of Clinical Oncology. |
| Keywords: | adolescent; adult; major clinical study; drug efficacy; vomiting; propofol; fever; intensive care; paracetamol; general anesthesia; anesthesia, general; hetastarch; drug half life; analgesics; bone marrow transplantation; ketorolac; anesthetic recovery; postoperative pain; pain, postoperative; transplantation, autologous; intravenous drug administration; fentanyl; middle age; vertigo; codeine; ambulatory surgery; ambulatory surgical procedures; human; male; female; priority journal; article; tolmetin; organ procurement |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 11 |
| Issue: | 2 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1993-02-01 |
| Start Page: | 320 |
| End Page: | 323 |
| Language: | English |
| DOI: | 10.1200/jco.1993.11.2.320 |
| PUBMED: | 8426210 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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