Phase II trial of zeniplatin (CL 286 558), a new patinum compound, in patients with advanced ovarian cancer previously treated with organoplatinum-based therapy Journal Article
| Authors: | Markman, M.; DeMarco, L. C.; Birkhofer, M.; Budman, D.; Hakes, T.; Reichman, B.; Rubin, S.; Jones, W.; Barakat, R.; Curtin, J.; Lewis, J. L. Jr; Almadrones, L.; Hoffman, A.; Rastogi, R.; Hoskins, W. |
| Article Title: | Phase II trial of zeniplatin (CL 286 558), a new patinum compound, in patients with advanced ovarian cancer previously treated with organoplatinum-based therapy |
| Abstract: | There is a critical need to find new chemotherapeutic agents that are active in platinum-refractory ovarian cancer. A phase II trial of zeniplatin (CL 286 558), a third-generation platinum compound, was conducted in 31 patients with advanced ovarian cancer to examine the safety and activity of the agent when used as a salvage treatment in individuals previously exposed to organoplatinum-based therapy. In general the drug was well tolerated, with moderate emesis and bone marrow suppression being observed in most patients. An unexpected side-effect was significant fever, of unknown etiology, which was noted in 16% of patients. Out of 20 patients, 2 (10%; 95% confidence intervals: 1%-32%) with clinically defined platinum-refractory disease achieved a partial response. Unfortunately, although we have defined definite but modest activity for zeniplatin in platinum-refractory ovarian cancer, further development of this drug has been discontinued because of the severe renal toxicity observed in other clinical trials of this cytotoxic agent. © 1993 Springer-Verlag. |
| Keywords: | adult; cancer chemotherapy; clinical article; aged; antineoplastic agents; ovarian cancer; ovarian neoplasms; carboplatin; nephrotoxicity; ovary cancer; phase 2 clinical trial; bone marrow suppression; vomiting; fever; platinum derivative; organoplatinum compounds; infusions, intravenous; intravenous drug administration; middle age; human; female; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; platinum drugs; zeniplatin |
| Journal Title: | Journal of Cancer Research and Clinical Oncology |
| Volume: | 119 |
| Issue: | 4 |
| ISSN: | 0171-5216 |
| Publisher: | Springer |
| Date Published: | 1993-04-01 |
| Start Page: | 234 |
| End Page: | 236 |
| Language: | English |
| DOI: | 10.1007/bf01624436 |
| PUBMED: | 8423199 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
