Phase II trial of gallium nitrate in previously treated patients with small cell lung cancer Journal Article
| Authors: | Baselga, J.; Kris, M. G.; Scher, H. I.; Phillips, M.; Heelan, R. T. |
| Article Title: | Phase II trial of gallium nitrate in previously treated patients with small cell lung cancer |
| Abstract: | Gallium nitrate is a group IIIa metal that was found to be active in animal species [1]. Gallium nitrate exerts its antitumor effects via a transferrin binding mechanism [2]. This agent is of interest in small cell lung cancer since 26 of 27 small cell carcinoma cell lines tested had increased levels of transferrin receptors [3]. In a phase I study using a continuous infusion, the dose limiting toxicity was nausea when gallium nitrate was given at doses of 400 mg/m2/day. Other effects included elevations of serum creatinine, hypocalcemia, hypomagnesemia, decreased hearing and paresthesias [4]. Activity has been seen in pretreated patients with malignant lymphoma, bladder carcinoma and small numbers of patients with small cell lung carcinoma [4, 5]. To determine the activity of continuous infusion gallium nitrate, this phase II trial was undertaken in patients with small cell lung cancer previously treated with chemotherapy. © 1993 Kluwer Academic Publishers. |
| Keywords: | adult; clinical article; aged; paresthesia; cisplatin; doxorubicin; cancer combination chemotherapy; drug efficacy; antineoplastic agents; phase 2 clinical trial; etoposide; nausea; lung neoplasms; creatinine; cyclophosphamide; vincristine; creatinine blood level; hypomagnesemia; lung small cell cancer; lactate dehydrogenase; drugs, investigational; infusions, intravenous; hearing loss; intravenous drug administration; transferrin; hypocalcemia; small cell lung cancer; carcinoma, small cell; magnesium ion; phase ii trial; middle age; gallium; calcium ion; gallium nitrate; human; male; female; priority journal; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Investigational New Drugs |
| Volume: | 11 |
| Issue: | 1 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 1993-02-01 |
| Start Page: | 85 |
| End Page: | 86 |
| Language: | English |
| DOI: | 10.1007/bf00873918 |
| PUBMED: | 8394297 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
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