Prediction equation estimates of creatinine clearance in the intensive care unit Journal Article
| Authors: | Pesola, G. R.; Akhavan, I.; Madu, A.; Shah, N. K.; Carlon, G. C. |
| Article Title: | Prediction equation estimates of creatinine clearance in the intensive care unit |
| Abstract: | Objective: To assess the accuracy of 4 mathematical equations used to estimate creatinine clearance versus the 24-h creatinine clearance in ICU patients. Design: Prospective study of renal function prediction. Setting: The general adult ICUs of 3 metropolitan hospitals. Patients: 199 critically ill patients with indwelling foley catheters. Intervention and measurements: Routine 24 h creatinine clearances were evaluated only in patients whose urine volume recorded by the nurses was within 10% of the laboratory's measured volume. Four mathematical equations utilizing age, sex, body weight, height, and plasma creatinine were used as a comparison. There was no difference in estimated creatinine clearance by 3 published methods when the 24 h creatinine clearance exceeded 100 ml/min. When the 24 h creatinine clearance was less than 100 ml/min, however, one prediction equation adjusted for lean body weight (LBW), was the most accurate. This equation accurately predicted creatinine clearance in the range of 30-100 ml/min and slightly overestimated creatinine clearance at 0-30 ml/min (p<0.01, ANOVA all groups, p<0.05 Fisher and Scheffé post-hoc tests) with a mean difference ±95% confidence interval of -5±3.1 ml/min. Conclusion: An initial rapid estimate of creatinine clearance in critically ill ICU patients with reduced renal function can be determined by an equation adjusted for LBW. © 1993 Springer-Verlag. |
| Keywords: | adult; aged; major clinical study; comparative study; prospective studies; accuracy; body weight; creatinine; creatinine blood level; age factors; prediction; age; intensive care; confidence intervals; intensive care unit; kidney function; predictive value of tests; intermethod comparison; body height; sex factors; regression analysis; analysis of variance; creatinine clearance; sex; urine volume; mathematical parameters; middle age; kidney function tests; human; male; female; article; cockcroft and gault; prediction equations |
| Journal Title: | Intensive Care Medicine |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 0342-4642 |
| Publisher: | Springer Verlag |
| Date Published: | 1993-01-01 |
| Start Page: | 39 |
| End Page: | 43 |
| Language: | English |
| DOI: | 10.1007/bf01709276 |
| PUBMED: | 8440797 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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