Protein splicing: Selfish genes invade cellular proteins Journal Article
| Author: | Neff, N. F. |
| Article Title: | Protein splicing: Selfish genes invade cellular proteins |
| Abstract: | Protein splicing is a series of enzymatic events involving intramolecular protein breakage, rejoining and intron homing, in which introns are able to promote the recombinative transposition of their own coding sequences. Eukaryotic and prokaryotic spliced proteins have conserved similar gene structure, but little amino acid identity. The genes coding for these spliced proteins contain internal in-frame introns that encode polypeptides that apparently self-excise from the resulting host protein sequences. Excision of the 'protein intron' is coupled with joining of the two flanking protein regions encoded by exons of the host gene. Some introns of this type encode DNA endonucleases, related to Group I RNA intron gene products, that stimulate gene conversion and self-transmission. © 1993. |
| Keywords: | exon; review; comparative study; gene; protein degradation; cell protein; intron; introns; evolution; gene conversion; protein processing; amino acid sequence; molecular sequence data; protein processing, post-translational; sequence homology, amino acid; sequence alignment; eukaryota; carrier proteins; peptide fragments; dna flanking region; gene structure; multigene family; endodeoxyribonucleases; endopeptidases; fungal proteins; prokaryota; genes, structural; rec a protein |
| Journal Title: | Current Opinion in Cell Biology |
| Volume: | 5 |
| Issue: | 6 |
| ISSN: | 0955-0674 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1993-12-01 |
| Start Page: | 971 |
| End Page: | 976 |
| Language: | English |
| DOI: | 10.1016/0955-0674(93)90079-6 |
| PUBMED: | 8129950 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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