Authors: | Dnistrian, A. M.; Schwartz, M. K.; Greenberg, E. J.; Smith, C. A.; Schwartz, D. C. |
Article Title: | Effect of tamoxifen on serum cholesterol and lipoproteins during chemohormonal therapy |
Abstract: | The effect of tamoxifen on serum cholesterol, high density lipoprotein cholesterol (HDL- low density lipoprotein cholesterol (LDL-cholesterol) and the ratio of LDL-cholesterol to HDL-cholesterol (LDL-C/HDL-C) was investigated in breast cancer patients undergoing therapy for advanced disease. Longitudinal studies in 24 patients treated with tamoxifen (10 mg, twice daily) indicated average decreases in total serum cholesterol (17%) and LDL-cholesterol (27%), whereas the effect of tamoxifen on HDL-cholesterol varied with the individual patient. There was a significant decrease in the LDL-C/HDL-C ratio (33%) consistent with a decreased risk for coronary artery disease. This beneficial influence of tamoxifen on risk factors associated with cardiovascular disease was evident in both premenopausal and postmenopausal patients whether tamoxifen was administered alone or in combination with cytotoxic chemotherapy. © 1993. |
Keywords: | clinical article; prednisone; doxorubicin; fluorouracil; methotrexate; antineoplastic agent; breast cancer; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; breast neoplasms; risk factor; cardiovascular disease; cardiovascular risk; cardiovascular diseases; tamoxifen; cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; cholesterol blood level; menopause; lipoproteins; human; female; priority journal; article; support, non-u.s. gov't; lipoprotein blood level; lipoproteins, hdl cholesterol; serum cholesterol; serum lipoproteins; lipoproteins, ldl cholesterol |
Journal Title: | Clinica Chimica Acta |
Volume: | 223 |
Issue: | 1-2 |
ISSN: | 0009-8981 |
Publisher: | Elsevier Science BV |
Date Published: | 1993-12-31 |
Start Page: | 43 |
End Page: | 52 |
Language: | English |
DOI: | 10.1016/0009-8981(93)90061-8 |
PUBMED: | 8143369 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Source: Scopus |