Effect of tamoxifen on serum cholesterol and lipoproteins during chemohormonal therapy Journal Article

  


Authors: Dnistrian, A. M.; Schwartz, M. K.; Greenberg, E. J.; Smith, C. A.; Schwartz, D. C.
Article Title: Effect of tamoxifen on serum cholesterol and lipoproteins during chemohormonal therapy
Abstract: The effect of tamoxifen on serum cholesterol, high density lipoprotein cholesterol (HDL- low density lipoprotein cholesterol (LDL-cholesterol) and the ratio of LDL-cholesterol to HDL-cholesterol (LDL-C/HDL-C) was investigated in breast cancer patients undergoing therapy for advanced disease. Longitudinal studies in 24 patients treated with tamoxifen (10 mg, twice daily) indicated average decreases in total serum cholesterol (17%) and LDL-cholesterol (27%), whereas the effect of tamoxifen on HDL-cholesterol varied with the individual patient. There was a significant decrease in the LDL-C/HDL-C ratio (33%) consistent with a decreased risk for coronary artery disease. This beneficial influence of tamoxifen on risk factors associated with cardiovascular disease was evident in both premenopausal and postmenopausal patients whether tamoxifen was administered alone or in combination with cytotoxic chemotherapy. © 1993.
Keywords: clinical article; prednisone; doxorubicin; fluorouracil; methotrexate; antineoplastic agent; breast cancer; antineoplastic combined chemotherapy protocols; cyclophosphamide; vincristine; breast neoplasms; risk factor; cardiovascular disease; cardiovascular risk; cardiovascular diseases; tamoxifen; cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; cholesterol blood level; menopause; lipoproteins; human; female; priority journal; article; support, non-u.s. gov't; lipoprotein blood level; lipoproteins, hdl cholesterol; serum cholesterol; serum lipoproteins; lipoproteins, ldl cholesterol
Journal Title: Clinica Chimica Acta
Volume: 223
Issue: 1-2
ISSN: 0009-8981
Publisher: Elsevier Science BV  
Date Published: 1993-12-31
Start Page: 43
End Page: 52
Language: English
DOI: 10.1016/0009-8981(93)90061-8
PUBMED: 8143369
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027769350&doi=10.1016%2f0009-8981%2893%2990061-8&partnerID=40&md5=ef0e8d1f3ed66a3b005b9784e2d92b45
Notes: Source: Scopus
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MSK Authors
  1. Ann Dnistrian
    78 Dnistrian
  2. Morton Schwartz
    186 Schwartz
  3. Delia C Schwartz
    45 Schwartz
  4. Carol Smith
    39 Smith
  5. Ernest J. Greenberg
    17 Greenberg
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