Octreotide as an antineoplastic agent in the treatment of functional and nonfunctional neuroendocrine tumors Journal Article

  

Authors:	Saltz, L.; Trochanowski, B.; Buckley, M.; Heffernan, B.; Niedzwiecki, D.; Tao, Y.; Kelsen, D.
Article Title:	Octreotide as an antineoplastic agent in the treatment of functional and nonfunctional neuroendocrine tumors
Abstract:	Background. Although patients with neuroendocrine tumors typically exhibit an indolent clinical course, the pace of disease accelerates and the prognosis deteriorates once objective progression of disease begins. Thirty‐four patients with advanced neuroendocrine tumors were treated with octreotide as antineoplastic therapy. This treatment was begun only after documentation of clear objective progression of disease. Methods. A Phase II trial was performed at a tertiary comprehensive cancer center. Results. The median survival for this patient population from the start of octreotide therapy has not been reached, with a median follow‐up of 29 months (range, 1–47 months). No major objective tumor regressions were seen. Seventeen patients (50%) experienced a computed tomography‐documented stabilization of disease that was maintainable for a minimum of 2 months (median, 5 months; range, 0–27 months). Of the 34 patients, 20 patients received octreotide as their first antineoplastic therapy. The median survival for these 20 patients has not been reached, with a median follow‐up also of 29 months (range, 12–41 months). Conclusions. Octreotide may influence the natural history of neuroendocrine tumors. The survival in patients treated with octreotide, as measured from the time of progression of disease, compares favorably with that of historical controls. Proof of a survival advantage for patients treated with octreotide would require a multicenter, randomized trial. Copyright © 1993 American Cancer Society
Keywords:	survival; adult; cancer survival; clinical article; aged; survival analysis; disease course; pancreatic neoplasms; neoplasm staging; phase 2 clinical trial; antineoplastic activity; tumor regression; neuroendocrine tumor; octreotide; tumor growth; carcinoid tumor; middle age; gastrins; adenoma, islet cell; subcutaneous drug administration; prognosis; human; male; female; priority journal; article; antineoplastic agent, neuroendocrine
Journal Title:	Cancer
Volume:	72
Issue:	1
ISSN:	0008-543X
Publisher:	Wiley Blackwell
Date Published:	1993-07-01
Start Page:	244
End Page:	248
Language:	English
DOI:	10.1002/1097-0142(19930701)72:1<244::Aid-cncr2820720143>3.0.Co;2-q
PUBMED:	8389666
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027198659&doi=10.1002%2f1097-0142%2819930701%2972%3a1%3c244%3a%3aAID-CNCR2820720143%3e3.0.CO%3b2-Q&partnerID=40&md5=c602112d8cb3d19afa7c68389562b6b9
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/143826