Primary peripheral nodal lymphoma in children Journal Article
| Authors: | Wollner, N.; Exelby, P.; Lindsley, K. L.; Lieberman, P.; Filippa, D.; Heller, G. |
| Article Title: | Primary peripheral nodal lymphoma in children |
| Abstract: | Background. In this series of 208 pediatric patients with non‐Hodgkin (NHL) studied from 1971 to 1986, 84 patients (40.4%) had nodal lymphomas; 40 (19.2%) of these patients had peripheral nodal lymphoma and 44 (21.2%) had mediastinal lymphoma. Methods. Forty pediatric patients with primary peripheral nodal lymphoma were treated at Memorial Sloan‐Kettering Cancer Center with the LSA2–L2 protocol from July 1971 to January 1986. Informed consent was obtained from all patients and/or guardians. Results. There were 26 male patients and 14 female patients, with a median age of 10 years. Two patients had Stage I disease, 5 Stage II, 9 Stage III, 8 Stage IVA (< 25% blasts in the bone marrow), and 16 Stage IVB (> 25% blasts in the bone marrow). The last patient with Stage IVB disease was entered in 1977, a time when the philosophy of treatment for leukemia‐lymphomas had not yet evolved completely. Most of these lymphomas were high‐grade lymphoblastic lymphomas, followed by immuno‐blastic lymphomas and reticulosarcomas. The event‐free survival rate of this group of patients was 75%, with all patients having completed therapy, and a median observation time of more than 10 years without therapy. The lymphoma‐free survival rate was 80%. Sex, age, and stage were not of prognostic significance. There was no significant difference in survival between patients with lymphoblastic and histiocytic lymphomas (75% versus 64%, respectively). There was no significant difference in survival between the patients with high‐grade and medium‐grade lymphomas (75% versus 78%, respectively). Lactic dehydrogenase (LDH) in this primary site was not indicative of extent or bulk of disease and did not affect survival negatively. Radiation therapy and dose intensity of chemotherapy influenced survival by promoting rapid and more complete cell kill, helping prevent the emergence of resistant cells. Conclusions. Although primary peripheral nodal lymphoma usually is disseminated at diagnosis, it is still a highly curable disease when treated aggressively. The lymphoma‐free survival rate for patients with primary nodal NHL with marrow involvement is 75%, and this subsequently has led to a different philosophy in the treatment of high‐risk leukemias and lymphoma‐leuke‐mias with the NY‐I and NY‐II protocols, with excellent results. Copyright © 1993 American Cancer Society |
| Keywords: | adolescent; cancer survival; child; clinical article; prednisone; histopathology; doxorubicin; cancer combination chemotherapy; cancer radiotherapy; cytarabine; methotrexate; cancer staging; lymph nodes; neoplasm staging; anemia; leukopenia; thrombocytopenia; antineoplastic combined chemotherapy protocols; radiotherapy dosage; cyclophosphamide; vincristine; kidney failure; pneumocystis pneumonia; nonhodgkin lymphoma; lymphoma, non-hodgkin; daunorubicin; asparaginase; sex factors; lymphoma, follicular; muscle atrophy; azoospermia; lymphoblastic lymphoma; convulsion; histiocytic lymphoma; prognosis; human; male; female; priority journal; article; thioguanine; non‐hodgkin lymphoma; lsa2–l2 protocol; nonlym‐phoblastic lymphoma; pediatric non‐hodgkin lymphoma; peripheral nodal lymphoma; malignant neurinoma |
| Journal Title: | Cancer |
| Volume: | 71 |
| Issue: | 11 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1993-06-01 |
| Start Page: | 3670 |
| End Page: | 3679 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19930601)71:11<3670::Aid-cncr2820711133>3.0.Co;2-s |
| PUBMED: | 8490916 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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